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Art. -Nr.: HY-N1034

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12-Oxocalanolide A

(Synonyms: (±)-12-Oxocalanolide A)

12-Oxocalanolide A (compound 6) is a potent inhibitor of reverse transcriptase from human immunodeficiency virus type 1 (HIV-1) with an IC₅₀ and EC₅₀ of 2.8 and 12 μM, respectively. 12-Oxocalanolide A is the analogue of Calanolide.

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CAS. Nr.: 161753-49-7
Formel: C₂₂H₂₄O₅
Molecular Weight:368.42

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (275 KB)

12-Oxocalanolide A Chemical Structure

CAS. Nr.: 161753-49-7

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Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- Cellular Effect
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

IC₅₀ & Target

HIV-1

Alle HIV Isoform-spezifische Produkte anzeigen :

Cellular Effect

Cell Line	Type	Value	Description	References
AA5	EC₅₀	2.8 μM Compound: (+/-)-2	Compound was evaluated for the anti-HIV activity against HIV strain IIIB in AA5 EBV-infected B-cell Compound was evaluated for the anti-HIV activity against HIV strain IIIB in AA5 EBV-infected B-cell	[PMID: 9873509]
B-cell	EC₅₀	>10 μM Compound: (+)-2	Compound was evaluated for the anti-HIV activity against HIV strain IIIB in AA5 EBV-infected B-cell Compound was evaluated for the anti-HIV activity against HIV strain IIIB in AA5 EBV-infected B-cell	[PMID: 9873509]
CCRF-CEM	EC₅₀	1.09 μM Compound: (+)-2	Compound was evaluated for the anti-HIV activity against HIV strain IIIB in CEM-SS T-cells Compound was evaluated for the anti-HIV activity against HIV strain IIIB in CEM-SS T-cells	[PMID: 9873509]
CCRF-CEM	EC₅₀	>10 μM Compound: (+)-2	Compound was evaluated for the anti-HIV activity against HIV strain IIIB in 174 x CEM T-cell:B-cell fusion Compound was evaluated for the anti-HIV activity against HIV strain IIIB in 174 x CEM T-cell:B-cell fusion	[PMID: 9873509]
CEM-SS	EC₅₀	0.15 μM Compound: 10	Using the XTT assay for cell viability, effective concentration to protect human lymphoblastoid CEM-SS cells from the cytopathic effects of HIV-1 (RF strain) was determined Using the XTT assay for cell viability, effective concentration to protect human lymphoblastoid CEM-SS cells from the cytopathic effects of HIV-1 (RF strain) was determined	[PMID: 8893846]
CEM-SS	IC₅₀	9.3 μM Compound: 10	Using the XTT assay for cell viability, inhibitory concentration to protect human lymphoblastoid CEM-SS cells from the cytopathic effects of HIV-1 (RF strain) was determined Using the XTT assay for cell viability, inhibitory concentration to protect human lymphoblastoid CEM-SS cells from the cytopathic effects of HIV-1 (RF strain) was determined	[PMID: 8893846]
CEM-SS	EC₅₀	1.2 μM Compound: (+/-)5	Concentration required to protect CEM-SS cells from HIV-1 mediated cytopathicity by 50% relative to drug-free controls was determined Concentration required to protect CEM-SS cells from HIV-1 mediated cytopathicity by 50% relative to drug-free controls was determined	[PMID: 9083491]
CEM-SS	IC₅₀	19 μM Compound: (+/-)5	Antiviral activity against HIV-1 determined by concentration which resulted in cytotoxicity of 50% of CEM-SS cell population relative to drug-free controls Antiviral activity against HIV-1 determined by concentration which resulted in cytotoxicity of 50% of CEM-SS cell population relative to drug-free controls	[PMID: 9083491]
CEM-SS	EC₅₀	0.52 μM Compound: (+/-)-2	Compound was evaluated for the anti-HIV activity against HIV strain IIIB in CEM-SS Value was expressed as EC50 Compound was evaluated for the anti-HIV activity against HIV strain IIIB in CEM-SS Value was expressed as EC50	[PMID: 9873509]

Chemical Information

CAS. Nr. 161753-49-7
Molecular Weight 368.42
Formel C₂₂H₂₄O₅
SMILES

O=C1C=C(CCC)C2=C3C(C=CC(C)(C)O3)=C4C(C([C@H](C)[C@@H](C)O4)=O)=C2O1
Synonyms

(±)-12-Oxocalanolide A
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (275 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Zembower DE, et al. Structural analogues of the calanolide anti-HIV agents. Modification of the trans-10,11-dimethyldihydropyran-12-ol ring (ring C). J Med Chem. 1997;40(6):1005-1017. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Biologische Aktivität
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12-Oxocalanolide A

Alle HIV Isoform-spezifische Produkte anzeigen

Biologische Aktivität

Chemical Information

Reinheit & Dokumentation

Verweise

Calculators

Help & FAQs

12-Oxocalanolide A Related Classifications

HY-N1034 Related Classifications