In vitro anti-human immunodeficiency virus (HIV) activity of the chromanone derivative, 12-oxocalanolide A, a novel NNRTI

  • Bioorg Med Chem Lett. 1998 Aug 18;8(16):2179-84. doi: 10.1016/s0960-894x(98)00380-1.
Z Q Xu  1 ,  R W Buckheit Jr ,  T L Stup ,  M T Flavin ,  A Khilevich ,  J D Rizzo ,  L Lin ,  D E Zembower
Affiliations
  • 1. MediChem Research Inc., Lemont, IL 60439, USA.
PMID: 9873509 DOI: 10.1016/s0960-894x(98)00380-1
Abstract

The three chromanone derivatives, (+)-, (-)-, and (+/-)-12-oxocalanolide A (2), were evaluated for in vitro Antiviral activities against HIV and simian immunodeficiency virus (SIV). The compounds were determined to be inhibitors of HIV-1 Reverse Transcriptase (RT) and exhibited activity against a variety of viruses selected for resistance to other HIV-1 nonnucleoside RT inhibitors. They are the first reported calanolide analogues capable of inhibiting SIV.