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Art. -Nr.: HY-184875

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B-Raf-IN-21

B-Raf-IN-21 is a B-Raf kinase inhibitor with a K_d of 4.8 nM and an IC₅₀ of 6 nM. B-Raf-IN-21 can be used for the research of stroke.

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CAS. Nr.: 342434-07-5
Formel: C₁₈H₁₉ClN₄O
Molecular Weight:342.83

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

B-Raf-IN-21 Chemical Structure

CAS. Nr.: 342434-07-5

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- In Vitro
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

B-Raf-IN-21 is a B-Raf kinase inhibitor with a K_d of 4.8 nM and an IC₅₀ of 6 nM. B-Raf-IN-21 can be used for the research of stroke^[1].

IC₅₀ & Target^[1]

B-Raf

4.8 nM (Kd)

B-Raf

6 nM (IC₅₀)

Alle Raf Isoform-spezifische Produkte anzeigen :

In Vitro

B-Raf-IN-21 (compound 8) potently inhibits B-Raf kinase with an IC₅₀ of 6 nM in a cell-free kinase activity assay^[1].
B-Raf-IN-21 binds to B-Raf with a K_d of 4.8 nM in a cell-free fluorescent polarization ligand binding assay^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS. Nr. 342434-07-5
Molecular Weight 342.83
Formel C₁₈H₁₉ClN₄O
SMILES

ClC=1C=CC(=CC1O)C=2NC(=NC2C=3C=CN=CC3)C(C)(C)CN
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Handling Instructions (2659 KB)

Verweise

[1]. Takle AK, et al. The identification of potent and selective imidazole-based inhibitors of B-Raf kinase. Bioorganic & medicinal chemistry letters. 2006 Jan 15;16(2):378-81. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- In Vitro
Chemical Information
Reinheit & Dokumentation
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B-Raf-IN-21

Alle Raf Isoform-spezifische Produkte anzeigen

Biologische Aktivität

Chemical Information

Reinheit & Dokumentation

Verweise

Calculators

Help & FAQs

B-Raf-IN-21 Related Classifications

HY-184875 Related Classifications