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BMS-505130 fumarate

BMS-505130 fumarate is a potent, selective and orally active serotonin transport inhibitor with a K_i for binding to the serotonin transporter of 0.18 nM (K_i for norepinephrine and dopamine transporters of 4.6 and 2.1 μM, respectively). BMS-505130 fumarate can be used for the research of neurological disease, such as depression.

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CAS. Nr.: 859230-84-5
Formel: C₁₉H₂₁N₃O₄
Molecular Weight:355.39

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (268 KB)

BMS-505130 fumarate Chemical Structure

CAS. Nr.: 859230-84-5

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Biologische Aktivität
- Beschreibung
- In Vivo
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Bioz

Biologische Aktivität

Beschreibung

Alle 5-HT Receptor Isoform-spezifische Produkte anzeigen :

In Vivo

BMS-505130 fumarate (5 mg/kg, p.o.) inhibits serotonin uptake in rats^[1].
BMS-505130 fumarate (1-30 mg/kg, i.p. or p.o.) produces a significant decrease in immobility time in depressant mice^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Depressant mice^[1]
Dosage:

1, 3, 10 and 30 mg/kg
Administration:

Intraperitoneally injection or Orally administration
Result:

Decreased immobility time in tail suspension test.

Chemical Information

CAS. Nr. 859230-84-5
Molecular Weight 355.39
Formel C₁₉H₂₁N₃O₄
SMILES

O=C(O)/C=C\C(O)=O.CN(C)C[C@@H]1[C@@H](C2=CNC3=CC=C(C#N)C=C23)C1
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (268 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Taber MT, et al. Neurochemical, pharmacokinetic, and behavioral effects of the novel selective serotonin reuptake inhibitor BMS-505130. Pharmacol Biochem Behav. 2005 Mar;80(3):521-8. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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