Bonducellpin D
Based on 1 Customer Validation
Bonducellpin D is a furanoditerpenoid lactone isolated from Caesalpinia minax. Bonducellpin D exhibits broad-spectrum inhibition potential against SARS-CoV Mpro and MERS-CoV Mpro, with an Ki of 467.11 and 284.86 nM, respectively. Bonducellpin D also exhibits moderate anti-cancer activity in vitro.
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- Reinheit: 98.0%
- CAS. Nr.: 197781-85-4
- Formel: C22H28O7
- Molecular Weight:404.45
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Speicherung:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Biologische Aktivität
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Chemical Information
- Reinheit & Dokumentation
- Verweise
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Help & FAQs
Biologische Aktivität
Ki: 467.11 nM (SARS-CoV Mpro), 284.86 nM (MERS-CoV Mpro)[1]
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| DU-145 | IC50 |
12 μM
Compound: Bonducellpin D
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Cytotoxicity against human DU145 cells after 24 to 72 hrs by MTT assay
Cytotoxicity against human DU145 cells after 24 to 72 hrs by MTT assay
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[PMID: 24303808] |
| HeLa | IC50 |
>50 μM
Compound: Bonducellpin D
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Cytotoxicity against human HeLa cells after 24 to 72 hrs by MTT assay
Cytotoxicity against human HeLa cells after 24 to 72 hrs by MTT assay
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[PMID: 24303808] |
| HepG2 | IC50 |
8 μM
Compound: Bonducellpin D
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Cytotoxicity against human HepG2 cells after 24 to 72 hrs by MTT assay
Cytotoxicity against human HepG2 cells after 24 to 72 hrs by MTT assay
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[PMID: 24303808] |
| K562 | IC50 |
>50 μM
Compound: Bonducellpin D
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Cytotoxicity against human K562 cells after 24 to 72 hrs by MTT assay
Cytotoxicity against human K562 cells after 24 to 72 hrs by MTT assay
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[PMID: 24303808] |
| RAW264.7 | IC50 |
25.4 μM
Compound: Caesalpinin H
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Anti-inflammatory activity against mouse RAW264.7 cells assessed as inhibition of LPS-induced NO production after 24 hrs by griess reagent assay
Anti-inflammatory activity against mouse RAW264.7 cells assessed as inhibition of LPS-induced NO production after 24 hrs by griess reagent assay
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[PMID: 36215157] |
Chemical Information
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CAS. Nr. 197781-85-4
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Appearance Solid
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Molecular Weight 404.45
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Formel C22H28O7
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Color White to off-white
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SMILES
O[C@]([C@H]1OC(C)=O)(C(C)(CC2)C)[C@@]([C@](CC(OC=C3)=C3[C@]45[H])([H])[C@@]4([H])[C@@]1([H])OC5=O)([C@H]2O)C
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Structure Classification
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Initial Source
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Reinheit & Dokumentation
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Data Sheet (276 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
Verweise
[1]. Gurung AB, et, al. Unravelling lead antiviral phytochemicals for the inhibition of SARS-CoV-2 M pro enzyme through in silico approach. Life Sci. 2020 Aug 15;255:117831. [Content Brief]
[2]. Zheng Y, et, al. Caesalminaxins A-L, cassane diterpenoids from the seeds of Caesalpinia minax. J Nat Prod. 2013 Dec 27; 76(12): 2210-8. [Content Brief]
[3]. Jiang RW, et, al. Molecular structures and antiviral activities of naturally occurring and modified cassane furanoditerpenoids and friedelane triterpenoids from Caesalpinia minax. Bioorg Med Chem. 2002 Jul;10(7):2161-70. [Content Brief]
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
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