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Ligelizumab

(Synonyms: QGE 031; Anti-IGHE Recombinant Antibody)
1 Cited Publications
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Based on 1 publication(s) in Google Scholar

Ligelizumab (QGE 031) is a humanized high-affinity anti-immunoglobulin IgE monoclonal antibody. Ligelizumab selectively inhibits the binding of IgE to the high-affinity receptor FcεRI, while the inhibitory effect on the low-affinity receptor CD23 is weak. Ligelizumab can inhibit the activation of effector cells such as mast cells and Basophil, while reducing the production of IgE by B cells, and restoring the IFN-α production and regulatory T cell (Treg) induction function of plasmacytoid dendritic cells (pDC). Ligelizumab can be used in the study of allergic diseases (such as chronic spontaneous urticaria, allergic asthma).

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  • Reinheit: 99.85%
  • CAS. Nr.: 1322627-61-1
  • Molecular Weight:146.32 kDa
  • Speicherung:

    Please store the product under the recommended conditions in the Certificate of Analysis.

  • Experimental Validation Results for Ligelizumab
  • Experimental Validation Results for Ligelizumab
  • Experimental Validation Results for Ligelizumab
  • Ligelizumab Chemical Structure
    Ligelizumab Chemical Structure
CAS. Nr.: 1322627-61-1
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To place orders, for customer services and technical support, please contact:

609-228-6898
[email protected] [email protected]
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Assay Types
  • 1/16

    Human IgG1 kappa

  • 1/16

    Immobilized IgE Fc Protein, Human can bind Ligelizumab. The EC50 for this effect is 4.31 ng/mL.

  • 1/16

    Loaded Ligelizumab on AHC2 biosensor, can bind IgE Protein, Human (HEK293, His, HY-P73907) with an affinity constant of 1.089E-12 M as determined in BLI assay.

  • Ligelizumab Chemical Structure
    1/16
  • Ligelizumab
  • Immobilized IgE Fc Protein, Human can bind Ligelizumab. The EC50 for this effect is 4.31 ng/mL.
  • Loaded Ligelizumab on AHC2 biosensor, can bind IgE Protein, Human (HEK293, His, HY-P73907) with an affinity constant of 1.089E-12 M as determined in BLI assay.