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Cat. No.: HY-169746

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Antiviral agent 63

Antiviral agent 63 is a nucleoside analog with anti-HCV activity. Antiviral agent 63 can inhibit viral replication by inhibiting the activity of HCV RNA-dependent RNA polymerase or other virus-related enzymes.

For research use only. We do not sell to patients.

CAS No.: 1613591-70-0
Formula: C₂₅H₃₃F₂N₆O₈P
Molecular Weight:614.54

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (271 KB)

Antiviral agent 63 Chemical Structure

CAS No.: 1613591-70-0

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- Cellular Effect
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

IC₅₀ & Target

RNA Polymerase

All DNA/RNA Synthesis Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
A549	CC₅₀	>100 μM Compound: 40	Cytotoxicity against human A549 cells incubated for 8 days by cellTiter-Glo assay Cytotoxicity against human A549 cells incubated for 8 days by cellTiter-Glo assay	[PMID: 32816483]
HeLa	CC₅₀	>100 μM Compound: 40	Cytotoxicity against human HeLa cells incubated for 8 days by cellTiter-Glo assay Cytotoxicity against human HeLa cells incubated for 8 days by cellTiter-Glo assay	[PMID: 32816483]
HepG2	CC₅₀	>100 μM Compound: 40	Cytotoxicity against human HepG2 cells incubated for 8 days by cellTiter-Glo assay Cytotoxicity against human HepG2 cells incubated for 8 days by cellTiter-Glo assay	[PMID: 32816483]
Huh-7	CC₅₀	>100 μM Compound: 40	Cytotoxicity against human HuH7 cells incubated for 8 days by cellTiter-Glo assay Cytotoxicity against human HuH7 cells incubated for 8 days by cellTiter-Glo assay	[PMID: 32816483]
Huh-7	CC₅₀	>100 μM Compound: 40	Cytotoxicity against human HuH7 cells infected with HCV con1 subgenomic replicon assessed as reduction in cell viability measured after 3 days by CellTiter-blue cell viability assay Cytotoxicity against human HuH7 cells infected with HCV con1 subgenomic replicon assessed as reduction in cell viability measured after 3 days by CellTiter-blue cell viability assay	[PMID: 32816483]
Huh-7	EC₅₀	0.014 μM Compound: 40	Antiviral activity against HCV con1 subgenomic replicon infected in human HuH7 cells assessed as reduction in viral RNA level by qRT-PCR analysis Antiviral activity against HCV con1 subgenomic replicon infected in human HuH7 cells assessed as reduction in viral RNA level by qRT-PCR analysis	[PMID: 32816483]
MT4	CC₅₀	92 μM Compound: 40	Cytotoxicity against human MT4 cells incubated for 8 days by cellTiter-Glo assay Cytotoxicity against human MT4 cells incubated for 8 days by cellTiter-Glo assay	[PMID: 32816483]
U-937	CC₅₀	10 μM Compound: 40	Cytotoxicity against human U937 cells incubated for 8 days by cellTiter-Glo assay Cytotoxicity against human U937 cells incubated for 8 days by cellTiter-Glo assay	[PMID: 32816483]

Chemical Information

CAS No. 1613591-70-0
Molecular Weight 614.54
Formula C₂₅H₃₃F₂N₆O₈P
SMILES

C[C@@]1([C@@H](O[C@@](F)([C@H]1O)COP(OC2=CC=CC=C2)(N[C@@H](C)C(OC(C)C)=O)=O)N3C4=NC(N)=NC(OCC)=C4N=C3)F
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (271 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Beigelman et al, Preparation of substituted nucleosides, nucleotides and analogs thereof as antitumor and HCV antiviral agents, WO2014100505, US, 2014-06-26.

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

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100 mg

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Biological Activity
- Description
- IC₅₀ & Target
Chemical Information
Purity & Documentation
References

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Antiviral agent 63

All DNA/RNA Synthesis Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

Antiviral agent 63 Related Classifications

HY-169746 Related Classifications