ANP32B - acidic nuclear phosphoprotein 32 family member B Gene

Also Known as APRIL; SSP29; PHAPI2

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 10541

About ANP32B

Cytogenetic location: 9q22.33 Genomic coordinates (GRCh38): 9:97,983,341-98,015,943 (from NCBI)

This gene has 3 transcripts (splice variants), 302 orthologues and 3 paralogues. Ubiquitous expression in bone marrow (RPKM 88.8), lymph node (RPKM 73.8) and 25 other tissues.

Summary

Enables RNA polymerase binding activity and histone binding activity. Involved in several processes, including activation of cysteine-type endopeptidase activity involved in apoptotic process; nucleosome assembly; and positive regulation of protein export from nucleus. Located in cytoplasm and nucleoplasm. Colocalizes with nucleolus. [provided by Alliance of Genome Resources, Apr 2022]

ANP32B Products (1)

mRNA Protein Name
NM_006401.3 NP_006392.1 acidic leucine-rich nuclear phosphoprotein 32 family member B

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables RNA polymerase binding IDA
IDA: Inferred from direct assay
9285060 GOA
enables histone binding IDA
IDA: Inferred from direct assay
20538007 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
21988832 GOA
Biological Process GO Annotation Evidence References Source
involved in activation of cysteine-type endopeptidase activity involved in apoptotic process IMP
IMP: Inferred from mutant phenotype
20015864 GOA
involved in negative regulation of cell differentiation IDA
IDA: Inferred from direct assay
22705300 GOA
involved in nucleosome assembly IDA
IDA: Inferred from direct assay
20538007 GOA
involved in positive regulation of protein export from nucleus IMP
IMP: Inferred from mutant phenotype
17178712 GOA
Cellular Component GO Annotation Evidence References Source
located in cytoplasm IDA
IDA: Inferred from direct assay
17178712 GOA
colocalizes with nucleolus IDA
IDA: Inferred from direct assay
9285060 GOA
located in nucleus IDA
IDA: Inferred from direct assay
9285060 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ANP32B Protein Structure

LRR_9

LRR_9: Leucine-rich repeat (17 - 149)

  • 0
  • 100
  • 200
  • 251 a.a.
Protein Preferred Names Protein Names

acidic leucine-rich nuclear phosphoprotein 32 family member B

  • acidic (leucine-rich) nuclear phosphoprotein 32 family, member B

ANP32B Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
ANP32B Q92688 BEND7 Homo sapiens Q8N7W2-2
Y2H Prey Pooling
32296183
Intra
ANP32B Q92688 BEND7 Homo sapiens Q8N7W2-2
Y2H Array
32296183
Intra
ANP32B Q92688 KIF1B Homo sapiens O60333-2
Y2H Array
32814053
Intra
ANP32B Q92688 KIF1B Homo sapiens O60333-2
Y2H Pooling
32814053
Intra
ANP32B Q92688 KIF1B Homo sapiens O60333-2
Validated Y2H
32814053
Intra
ANP32B Q92688 YAF2 Homo sapiens Q8IY57-5
Y2H Array
32296183
Intra
ANP32B Q92688 YAF2 Homo sapiens Q8IY57-5
Y2H Prey Pooling
32296183
Intra
ANP32B Q92688 FAM217B Homo sapiens Q9NTX9
Validated Y2H
32296183
Intra
ANP32B Q92688 FAM217B Homo sapiens Q9NTX9
Y2H Prey Pooling
32296183
Intra
ANP32B Q92688 FAM217B Homo sapiens Q9NTX9
Y2H Array
32296183
Intra
ANP32B Q92688 DNTTIP1 Homo sapiens Q9H147
Validated Y2H
32296183
Intra
ANP32B Q92688 DNTTIP1 Homo sapiens Q9H147
Y2H Array
32296183
Intra
ANP32B Q92688 DNTTIP1 Homo sapiens Q9H147
Y2H Prey Pooling
32296183
Intra
ANP32B Q92688 MYNN Homo sapiens Q9NPC7
Y2H Prey Pooling
32296183
Intra
ANP32B Q92688 MYNN Homo sapiens Q9NPC7
Validated Y2H
32296183
Intra
ANP32B Q92688 MYNN Homo sapiens Q9NPC7
Y2H Array
32296183
Intra
ANP32B Q92688 HSPB1 Homo sapiens P04792
Y2H Pooling
32814053
Intra
ANP32B Q92688 HSPB1 Homo sapiens P04792
Validated Y2H
32814053
Intra
ANP32B Q92688 HSPB1 Homo sapiens P04792
Y2H Array
32814053
Intra
ANP32B Q92688 KPNA1 Homo sapiens P52294
Y2H Prey Pooling
32296183
Intra
ANP32B Q92688 KPNA1 Homo sapiens P52294
Y2H Array
25416956
Intra
ANP32B Q92688 KPNA1 Homo sapiens P52294
Y2H Array
32296183
Intra
ANP32B Q92688 KPNA6 Homo sapiens O60684
Y2H Array
32296183
Intra
ANP32B Q92688 KPNA6 Homo sapiens O60684
Y2H Prey Pooling
32296183
Intra
ANP32B Q92688 KPNA5 Homo sapiens O15131
Y2H Prey Pooling
32296183
Intra
ANP32B Q92688 KPNA5 Homo sapiens O15131
Y2H Array
31515488
Intra
ANP32B Q92688 KPNA5 Homo sapiens O15131
Y2H Array
32296183
Intra
ANP32B Q92688 WFS1 Homo sapiens O76024
Y2H Array
32814053
Intra
ANP32B Q92688 WFS1 Homo sapiens O76024
Y2H Pooling
32814053
Intra
ANP32B Q92688 WFS1 Homo sapiens O76024
Validated Y2H
32814053
Intra
ANP32B Q92688 SDCBP Homo sapiens O00560
Y2H Array
32296183
Intra
ANP32B Q92688 SDCBP Homo sapiens O00560
Y2H Prey Pooling
32296183
Intra
ANP32B Q92688 SDCBP Homo sapiens O00560
Validated Y2H
25416956
Cross: Cross-species interaction Intra: Intraspecies interaction

ANP32B Antibodies

Cat. No. Product Name Application Reactivity
HY-P81865 PHAPI2/APRIL Antibody (YA1610) WB, IHC-F, IHC-P, ICC/IF Human, Rat
HY-P81865A PHAPI2/APRIL Antibody (YA1610)(PBS only) WB, IHC-F, IHC-P, ICC/IF Human, Rat
HY-P82513 PHAPI2/APRIL Antibody (YA2258) WB, ICC/IF Human, Mouse, Rat

Related Diseases

Diseases Alias
Influenza

  • Flu

  • Influenza With Non-Respiratory Manifestation

  • Influenza With Other Manifestations

  • Influenza, Human

  • Influenza, Susceptibility To

  • Seasonal Influenza, Virus Identified
Myopathy, Congenital, Compton-North

  • Compton-North Congenital Myopathy

  • MYPCN

  • Congenital Lethal Myopathy, Compton-North Type
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-184486 ANDS / Unkown
HY-RS00752 ANP32B Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus ANP32B VGNC VGNC:59835
Rattus norvegicus ANP32B RGD RGD:621285
Macaca mulatta ANP32B VGNC VGNC:103240
Canis familiaris ANP32B VGNC VGNC:37933
Bos taurus ANP32B VGNC VGNC:25958
Mus musculus ANP32B MGD MGI:1914878
Others ANP32B NCBI