SUZ12 - SUZ12 polycomb repressive complex 2 subunit Gene

Also Known as CHET9; IMMAS; JJAZ1

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 23512

About SUZ12

Cytogenetic location: 17q11.2 Genomic coordinates (GRCh38): 17:31,937,007-32,001,038 (from NCBI)

This gene has 4 transcripts (splice variants), 275 orthologues and is associated with 92 phenotypes. Ubiquitous expression in testis (RPKM 13.7), lymph node (RPKM 12.3) and 25 other tissues.

Summary

This zinc finger gene has been identified at the breakpoints of a recurrent chromosomal translocation reported in endometrial stromal sarcoma. Recombination of these breakpoints results in the fusion of this gene and JAZF1. The protein encoded by this gene contains a zinc finger domain in the C terminus of the coding region. [provided by RefSeq, Jul 2009]

SUZ12 Products (2)

mRNA Protein Name
NM_001321207.2 NP_001308136.1 polycomb protein SUZ12 isoform 2
NM_015355.4 NP_056170.2 polycomb protein SUZ12 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables enzyme activator activity IMP
IMP: Inferred from mutant phenotype
15385962 GOA
enables methylated histone binding IDA
IDA: Inferred from direct assay
21029866 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
17560333 GOA
enables transcription corepressor binding IPI
IPI: Inferred from physical interaction
29628311 GOA
Biological Process GO Annotation Evidence References Source
involved in negative regulation of cell differentiation IMP
IMP: Inferred from mutant phenotype
19847889 GOA
Cellular Component GO Annotation Evidence References Source
part of ESC/E(Z) complex IDA
IDA: Inferred from direct assay
20075857 GOA
part of ESC/E(Z) complex IMP
IMP: Inferred from mutant phenotype
15385962 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SUZ12 Protein Structure

VEFS-Box

VEFS-Box: VEFS-Box of polycomb protein (545 - 681)

  • 0
  • 200
  • 400
  • 600
  • 739 a.a.
Protein Preferred Names Protein Names

polycomb protein SUZ12

  • chET 9 protein

SUZ12 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
SUZ12 Q15022 JARID2 Homo sapiens Q92833-1
Anti Tag CoIP
20075857
Intra
SUZ12 Q15022 JARID2 Homo sapiens Q92833-1
Anti Bait CoIP
20075857
Intra
SUZ12 Q15022 EZH2 Homo sapiens Q15910
Anti Bait CoIP
20075857
Intra
SUZ12 Q15022 EZH2 Homo sapiens Q15910
Anti Bait CoIP
23079660
Intra
SUZ12 Q15022 EZH2 Homo sapiens Q15910
Anti Tag CoIP
20075857
Intra
SUZ12 Q15022 EZH2 Homo sapiens Q15910
CH-IP
23238014
Intra
SUZ12 Q15022 EZH2 Homo sapiens Q15910
Anti Bait CoIP
22439931
Intra
SUZ12 Q15022 HDAC3 Homo sapiens O15379
Anti Bait CoIP
23079660
Intra
SUZ12 Q15022 PML-RAR Homo sapiens Q15156
Anti Bait CoIP
17560333
Intra
SUZ12 Q15022 EED Homo sapiens O75530
Anti Bait CoIP
22439931
Intra
SUZ12 Q15022 EED Homo sapiens O75530
Anti Tag CoIP
35016035
Intra
SUZ12 Q15022 EED Homo sapiens O75530
Anti Tag CoIP
20075857
Intra
SUZ12 Q15022 EED Homo sapiens O75530
Anti Tag CoIP
20543829
Intra
SUZ12 Q15022 EED Homo sapiens O75530
TAP
24981860
Intra
SUZ12 Q15022 EED Homo sapiens O75530
TAP
27705803
Intra
SUZ12 Q15022 EED Homo sapiens O75530
Anti Tag CoIP
33961781
Cross: Cross-species interaction Intra: Intraspecies interaction

SUZ12 Antibodies

Cat. No. Product Name Application Reactivity
HY-P80353 SUZ12 Antibody (YA044) WB, ICC/IF, IP Human, Mouse, Rat
HY-P83440 SUZ12 Antibody (YA3185) WB, ICC/IF, IP Human, Mouse, Rat
HY-P85378 SUZ12 Antibody (YA5070) ICC/IF Human
HY-P86583 SUZ12 Antibody (YA6275) WB, IHC-P, ICC/IF, IP, ELISA Human, Mouse, Rat

Related Diseases

Diseases Alias
Imagawa-Matsumoto Syndrome

  • IMMAS
Endometrial Stromal Sarcoma

  • Ess

  • Endometrial Stromal Sarcoma, High Grade

  • Undifferentiated Endometrial Sarcoma

  • Stromal Sarcoma Of The Corpus Uteri

  • Sarcoma Endometrial Stromal

  • Sarcoma, Endometrial Stromal

  • Undifferentiated Stromal Sarcoma
Weaver Syndrome

  • Wss

  • Weaver-Smith Syndrome

  • WVS

  • Weaver-Like Syndrome

  • Weaver-Williams Syndrome

  • Camptodactyly-Overgrowth-Unusual Facies Syndrome

  • Camptodactyly - Overgrowth - Unusual Facies

  • Ezh2 Related Overgrowth

  • Overgrowth Syndrome With Accelerated Skeletal Maturation, Unusual Facies, And Camptodactyly

  • Weaver Smith Syndrome

  • Weaver Like Syndrome

  • Weaver Williams Syndrome

  • Camptodactyly-Overgrowth-Unusual Facies

  • Weaver Syndrome 1

  • Weaver Syndrome 2

  • Wvs1

  • Wvs2
Acute Megakaryoblastic Leukemia In Down Syndrome

  • Ds-Amkl
Atypical Neurofibroma
Endometrial Stromal Tumor

  • Endometrial Stromal Neoplasm

  • Endometrial Stromal Tumors
Plexiform Neurofibroma

  • Neurofibroma Plexiform

  • Neurofibroma, Plexiform
Endometrial Stromal Nodule
Sarcoma

  • Connective And Soft Tissue Neoplasm

  • Tumor Of Soft Tissue And Skeleton

  • Sarcomas

  • Sarcoma - Category
Vaginal Endometrial Stromal Sarcoma
Vagina Sarcoma

  • Sarcoma Of The Vagina

  • Vaginal Sarcoma
Diffuse Large B-Cell Lymphoma

  • Dlbcl

  • Diffuse Large B-Cell Lymphoma, Not Otherwise Specified

  • Large B-Cell Diffuse Lymphoma

  • Lymphoma, Large B-Cell, Diffuse

  • Dlbcl - [Diffuse Large B-Cell Lymphoma]

  • Diffuse Large Beta Cell Lymphoma
Childhood Malignant Schwannoma

  • Pediatric Mpnst

  • Childhood Neurofibrosarcoma
Cellular Leiomyoma
Adult Malignant Schwannoma

  • Adult Mpnst

  • Adult Neurofibrosarcoma
Epithelioid Malignant Peripheral Nerve Sheath Tumor

  • Epithelioid Mpnst

  • Malignant Epithelioid Neoplasm Of The Peripheral Nerve Sheath
Colorectal Cancer

  • Colon Cancer

  • Colorectal Carcinoma

  • Colon Carcinoma

  • Colorectal Cancer, Susceptibility To

  • Carcinoma Of Colon

  • CRC

  • Colorectal Cancer With Chromosomal Instability, Somatic

  • Colon Cancer, Somatic

  • Colon Cancer, Susceptibility To

  • Colonic Neoplasms

  • Colorectal Neoplasms

  • Colorectal Cancer, Somatic

  • Colon Cancer, Advanced, Somatic

  • Colonic Carcinoma

  • Colorectal Carcinomas

  • Colon Cancers

  • Colorectal Cancers

  • Cancer, Colorectal, Somatic

  • Cancer, Colon

  • Cancer, Colorectal, Susceptibility To

  • Colorectal Neoplasm

  • Colonic Neoplasm

  • Malignant Tumor Of Colon
Ovarian Sex-Cord Stromal Tumor

  • Ovarian Sex Cord Tumor With Annular Tubules

  • Ovarian Sex Cord-Stromal Tumor

  • Stromal Tumor Of Ovary
Neurofibrosarcoma

  • Neurosarcoma

  • Malignant Peripheral Nerve Sheath Tumor
Cervical Adenosarcoma

  • Cervical Muellerian Adenosarcoma

  • Cervical Mullerian Adenosarcoma
Neurilemmomatosis

  • Schwannomatosis

  • Neurofibromatosis Type 3

  • Nf3

  • Neurilemmomatosis Congenital Cutaneous

  • Neurinomatosis

  • Congenital Cutaneous Neurilemmomatosis

  • Multiple Neurilemmomas

  • Multiple Schwannomas

  • Neurilemmomatosis, Congenital Cutaneous

  • Schwannomatosis 1

  • Neurofibromatosis 3

  • Mixed Central And Peripheral Neurofibromatosis

  • Nf3 - [Neurofibromatosis Type 3]
Immunodeficiency-Centromeric Instability-Facial Anomalies Syndrome

  • Icf Syndrome

  • Immunodeficiency Syndrome, Variable

  • Ciid

  • Centromeric Instability, Immunodeficiency Syndrome

  • Immune Deficiency, Variable, With Centromeric Instability Of Chromosomes 1, 9, And 16

  • Icf
Leukemia, Acute Myeloid

  • Acute Myeloid Leukemia

  • Leukemia, Acute Myelogenous

  • Acute Myelogenous Leukemia

  • AML

  • Leukemia, Acute Myeloid, Susceptibility To

  • Acute Myeloblastic Leukemia

  • Leukemia, Acute Myeloid, Reduced Survival In, Somatic

  • Acute Myeloid Leukaemia

  • Leukemia, Myelocytic, Acute

  • Therapy Related Acute Myeloid Leukemia And Myelodysplastic Syndrome

  • Secondary Aml

  • Acute Myelocytic Leukemia

  • Acute Myeloid Leukemia, Somatic

  • Leukemia, Acute Myeloid, Somatic

  • Myeloid Leukemia, Acute, M4/M4eo Subtype, Somatic

  • Acute Myeloblastic Leukaemia

  • Acute Myelogenous Leukaemia

  • Aml - Acute Myeloid Leukemia

  • Acute Myeloid Leukemia With Cebpa Somatic Mutations

  • Aml With Cebpa Somatic Mutations

  • Inherited Acute Myeloid Leukemia

  • Familial Aml

  • Inherited Aml

  • Pure Familial Aml

  • Pure Familial Acute Myeloid Leukemia

  • Secondary Acute Myeloid Leukemia

  • Therapy-Related Aml And Myelodysplastic Syndrome

  • Acute Myeloid Leukemia, Secondary

  • Acute Non-Lymphoblastic Leukemia

  • Acute Non-Lymphocytic Leukemia

  • Acute Biphenotypic Leukemia

  • Acute Undifferentiated Leukemia

  • Acute Myeloblastic Leukaemia With Multilineage Dysplasia

  • Acute Myeloid Leukaemia With Multilineage Dysplasia Without Mention Of Remission

  • Acute Myeloid Leukaemia With Myelodysplasia-Related Features
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (17)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-130708 UNC6852 Inhibitor 98.49% Unkown
HY-101512 A-395 Inhibitor 99.12% Unkown
HY-148334 MS8815 Degrader 99.95% Unkown
HY-W014099 Boc-NH-C4-acid 99.65% Unkown
HY-130638 (S,R,S)-AHPC-O-Ph-PEG1-NH-Boc / Unkown
HY-101512D rel-A-395 hydrochloride Inhibitor / Unkown
HY-130637 Boc-NH-PEG1-Ph-O-CH2COOH / Unkown
HY-168131 PROTAC EZH2 Degrader-3 / Unkown
HY-174372 EZH2-IN-23 Inhibitor / Unkown
HY-181308 PROTAC EZH2 Degrader-13 Degrader / Unkown
HY-181320 PROTAC EZH2 Degrader-19 Degrader / Unkown
HY-181323 PROTAC EZH2 Degrader-22 Degrader / Unkown
HY-181392 PROTAC EZH2 Degrader-35 Degrader / Unkown
HY-181413 PROTAC EZH2 Degrader-44 / Unkown
HY-RS14053 SUZ12 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS17149 Suz12 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23598 Suz12 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus SUZ12 VGNC VGNC:65859
Bos taurus SUZ12 VGNC VGNC:35493
Macaca mulatta SUZ12 VGNC VGNC:78144
Mus musculus SUZ12 MGD MGI:1261758
Canis familiaris SUZ12 VGNC VGNC:47002
Rattus norvegicus SUZ12 RGD RGD:1593621
Others SUZ12 NCBI