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Cat. No.: HY-181323

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PROTAC EZH2 Degrader-22

PROTAC EZH2 Degrader-22 (compound 7) is a PROTAC protein degrader targeting EZH2. PROTAC EZH2 Degrader-22 is applicable to cancer-related research.
(Pink: EZH2 ligand (HY-13470); Blue: Cereblon ligand (HY-103596); Black: linker).

For research use only. We do not sell to patients.

CAS No.: 2653338-66-8
Formula: C₅₄H₆₆N₈O₇
Molecular Weight:939.15

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

PROTAC EZH2 Degrader-22 Chemical Structure

CAS No.: 2653338-66-8

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
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Biological Activity

Description

PROTAC EZH2 Degrader-22 (compound 7) is a PROTAC protein degrader targeting EZH2. PROTAC EZH2 Degrader-22 is applicable to cancer-related research^[1]. (Pink: EZH2 ligand (HY-13470); Blue: Cereblon ligand (HY-103596); Black: linker).

All PROTACs Isoforms :

All Histone Methyltransferase Isoforms :

In Vitro

PROTAC EZH2 Degrader-22 (compound 7) exhibits concentration- and time-dependent activity, with degradation reversed by co-treatment with CRBN ligand, proteasome inhibitor, or NAE inhibitor; mRNA levels of PRC2 subunits remain unaffected, excluding transcriptional regulation^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 2653338-66-8
Molecular Weight 939.15
Formula C₅₄H₆₆N₈O₇
SMILES

CC[C@@H](N1C2=CC(C3=CN=C(C=C3)N4CCN(CC4)CCCCCCCCCCOC5=C(C6=CC=C5)C(N(C6=O)C7CCC(NC7=O)=O)=O)=CC(C(NCC8=C(C=C(NC8=O)C)C)=O)=C2C(C)=C1)C
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. S Abulkhair H, et al. Therapeutic horizons in the development of PROTAC-based EZH2 inhibitors: recent achievements, comparative analysis, and future perspectives. RSC Adv. 2026;16(4):3034-3056. Published 2026 Jan 14. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Biological Activity
- Description
- In Vitro
Chemical Information
Purity & Documentation
References

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PROTAC EZH2 Degrader-22

All PROTACs Isoforms

All Histone Methyltransferase Isoforms