Partricin B
Partricin B is an aromatic heptaene macrolide with antifungal and antiprotozoal activities. Partricin B interacts with cholesterol via the polyene side of the plane of its macrolide ring; its all-trans photoisomer interacts with cholesterol via the opposite region and shows no tendency to bind to the polyene region. Partricin B can be used in studies related to fungal infections.
For research use only. We do not sell to patients.
- CAS No.: 76551-65-0
- Formula: C58H84N2O19
- Molecular Weight:1113.29
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Partricin B interacts weakly with Cholesterol (Cholesterol (from animal)) (HY-N0322) via its polyene ring plane at a centre-of-mass distance of ~8 Å, and exhibits both weak polyene binding and stronger polyol-region binding with Ergosterol (HY-N0181) at centre-of-mass distances of ~8 Å and ~6 Å, respectively, in DPPC lipid bilayers[1].
Partricin B interacts with cholesterol via a region opposite to that preferred by native partricin B with shallow energetic minima, and interacts with ergosterol in a similar pattern to native partricin B but with ~3 kcal/mol weaker binding, in DPPC lipid bilayers[1].
Partricin B retroaldol reaction releases acetaldehyde and acetone in a molar ratio of 2-3:1[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 76551-65-0
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Molecular Weight 1113.29
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Formula C58H84N2O19
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SMILES
O=C(O[C@H]([C@@H](C)CC[C@@H](O)CC(C1=CC=C(N)C=C1)=O)[C@@H](C)/C=C/C=C/C=C\C=C/C=C/C=C/C=C/[C@H](O[C@H]2[C@@H](O)[C@@H](N)[C@H](O)[C@@H](C)O2)C3)C[C@H](O)CC(C[C@H](O)C[C@H](O)C[C@H](O)C[C@H](O)C[C@]4(O)C[C@H](O)[C@@H](C(O)=O)[C@H]3O4)=O
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Structure Classification
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Initial Source
Streptomyces aureofaciens
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. Borzyszkowska-Bukowska J, et al. Antibiotic-sterol interactions provide insight into the selectivity of natural aromatic analogues of amphotericin B and their photoisomers. Scientific reports. 2023 Jan 14;13(1):762. [Content Brief]
[2]. Szczeblewski P, et al. Iso-Partricin, an Aromatic Analogue of Amphotericin B: How Shining Light on Old Drugs Might Help Create New Ones. Antibiotics (Basel, Switzerland). 2021 Sep 13;10(9):1102. [Content Brief]
[3]. Tweit RC, et al. Characterization of the antifungal and antiprotozoal antibiotic partricin and structural studies on partricins A and B. The Journal of antibiotics. 1982 Aug;35(8):997-1012. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Partricin B Related Classifications
HY-N21837 Related Classifications
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