301 Results for "

information

" in MedChemExpress (MCE) Product Catalog:
Products (301)

301 Results for "information" in MCE Product Catalog:

5
5 Cited Publications
Cat. No.: HY-P71596
Purity:  ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: SIRT1; Sirtuin (Silent Mating Type information Regulation 2, S. Cerevisiae, Homolog) 1; Sirtuin 1; Sirtuin (Silent Mating Type information Regulation 2 Homolog) 1 (S. Cerevisiae); SIR2L1; Protein Acetyllysine N-Acetyltransferase; NAD-Dependent Protein Dea
Species:  
Source:  
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2
2 Cited Publications
Cat. No.: HY-P74545
Purity:  ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: SIRT5; Sirtuin (Silent Mating Type information Regulation 2, S.Cerevisiae, Homolog) 5; Sirtuin 5; NAD-Dependent Lysine Demalonylase And Desuccinylase Sirtuin-5, Mitochondrial; NAD-Dependent Protein Deacylase Sirtuin-5, Mitochondrial; Silent Mating Type In
Species:  
Source:  
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Cat. No.: HY-P2847
CAS No.: 330648-32-3
Target:  

CRFR

Research Areas:  

Metabolic Disease Endocrinology

Urocortin II, mouse is a potent and selective endogenous peptide agonist of type-2 corticotropin-releasing factor (CRF2) receptor with Ki values of 0.66 nM and ﹥100 nM for CRFR2 and CRFR1, respectively. Urocortin II, mouse activates CRF2 receptors in a cAMP/PKA- and Ca 2+/CaMKII-dependent manner.Urocortin II, mouse is expressed in discrete areas of the central nervous system, and activates central neurons involved in the processing of visceral sensory information, and in modulating autonomic outflow .
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Cat. No.: HY-133685
CAS No.: 147852-83-3
Purity:  98.82%
Synonyms: C6-HSL
Target:  

Bacterial

Research Areas:  

Infection Metabolic Disease

N-Hexanoyl-L-homoserine lactone is a short-chained N-acyl homoserine lactone (AHL). N-hexanoyl-L-homoserine lactone is also a mediator of bacterial quorum-sensing regulation. N-hexanoyl-L-homoserine lactone promotes lipid accumulation in algae. AHL is an intercellular communication signal molecule in the quorum sensing system of Gram-negative bacteria and a medium for mediating information exchange between eukaryotic plants and prokaryotic bacteria. AHL can affect bacteria activities, such as biofilm formation, pigment synthesis, and antibiotic synthesis .
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Cat. No.: HY-N2126
CAS No.: 952068-57-4
Parishin E is a modulator of hexokinase 2, lactate dehydrogenase A, and silent information regulator 6 (sirtuin 6), and is also a component present in Gastrodia elata Blume . Parishin E reduces the expression of hexokinase 2 and lactate dehydrogenase A, thereby regulating the process of cellular glycolysis . Parishin E regulates the deacetylation mediated by silent information regulator 6 (Sirtuin 6), and inhibits histone 3 lactylation modifications at the H3K18la and H3K27la sites . Parishin E inhibits macrophage polarization . Parishin E alleviates LPS-induced inflammatory responses and suppresses the expression of pro-inflammatory cytokines . Parishin E exerts ameliorating effects on rheumatoid arthritis . Parishin E can be used in studies related to rheumatoid arthritis .
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Cat. No.: HY-Y0982
CAS No.: 76189-56-5
Research Areas:  

Others

(S)-BINAP is an isomer of (R)-BINAP (HY-W017757), as well as a chiral chelating diphosphine ligand and enantioselective catalyst precursor. (S)-BINAP acts as a bidentate ligand, transferring chiral information via its binaphthyl backbone to achieve stereodiscrimination of substrates. (S)-BINAP is used for the enantioselective hydrogenation of prochiral carboxylic acids, N-acyltetrahydroisoquinolines, allylic alcohols, functionalized ketones, cyclic anhydrides, and styrenes .
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Cat. No.: HY-137989A
Purity:  99.52%
Synonyms: Voriconazole oxynitride hydrochloride
Target:  

Drug Metabolite

Research Areas:  

Infection

Voriconazole N-oxide (Voriconazole oxynitride) (hydrochloride) is the main metabolite of Voriconazole (HY-76200) , a widely used triazole antibiotic (fungal). Voriconazole N-oxide (hydrochloride) provides information on the patient's drug metabolism capacity .
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Cat. No.: HY-146689
CAS No.: 2470969-89-0
Purity:  98.86%
Target:  

Sirtuin

Research Areas:  

Cancer

SIRT1-IN-2 (compound 3h) is a potent and selective SIRT1 (silent information regulator 1) inhibitor, with an IC50 of 1.6 μM .
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Cat. No.: HY-145588A
CAS No.: 1637677-33-8
Purity:  98.82%
Synonyms: INCB54707 phosphate
Target:  

JAK

Research Areas:  

Inflammation/Immunology

Povorcitinib (INCB54707) phosphate is a potent and selective JAK1 inhibitor that effectively reduces abscesses and inflammatory nodules. Povorcitinib phosphate can be used to study cutaneous lupus erythematosus (CLE) and lichen planus (LP) (information extracted from patent WO2021076124A1) .
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Cat. No.: HY-132138A
Purity:  98.02%
Target:  

DNA/RNA Synthesis

Research Areas:  

Others

5-Propargylamino-3'-azidomethyl-dCTP (TEA) is a nucleotide molecule that can be used in DNA synthesis and DNA sequencing. For detailed information, refer to compound 17 in patent document WO2004018497A2. 5-Propargylamino-3'-azidomethyl-dCTP (TEA) is a click chemistry reagent containing an azide group, which can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing alkyne groups. It can also react with molecules containing DBCO or BCN groups through strain-promoted alkyne-azide cycloaddition (SPAAC) .
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Cat. No.: HY-133685R
CAS No.: 147852-83-3
Synonyms: C6-HSL (Standard)
Research Areas:  

Infection Metabolic Disease

N-Hexanoyl-L-homoserine lactone (Standard) is the analytical standard of N-Hexanoyl-L-homoserine lactone (HY-133685). This product is intended for research and analytical applications. N-Hexanoyl-L-homoserine lactone is a short-chained N-acyl homoserine lactone (AHL). N-hexanoyl-L-homoserine lactone is also a mediator of bacterial quorum-sensing regulation. N-hexanoyl-L-homoserine lactone promotes lipid accumulation in algae. AHL is an intercellular communication signal molecule in the quorum sensing system of Gram-negative bacteria and a medium for mediating information exchange between eukaryotic plants and prokaryotic bacteria. AHL can affect bacteria activities, such as biofilm formation, pigment synthesis, and antibiotic synthesis.
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Cat. No.: HY-14843
CAS No.: 610300-07-7
Synonyms: PD-0332334free base
Target:  

GABA Receptor

Research Areas:  

Neurological Disease

Imagabalin (PD-0332334 free base) is an active compound with activity for studying neurological diseases. The synthesis of imagabalin involves the reaction of 3-methylvaleric acid and Meldrum acid. During the synthesis of imagabalin, an acyl chloride intermediate species, 3-methylvaleryl chloride, was revealed for the first time. The synthesis of imagabalin also provided new information about the reaction mechanism, indicating that 3-methylvaleric anhydride is an important intermediate .
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Cat. No.: HY-113218S
CAS No.: 203805-90-7
Synonyms: O-Acetyl-L-carnitine-d9; ALCAR-d9
Acetyl-L-carnitine-d9 (O-Acetyl-L-carnitine-d9) is deuterium labeled Acetyl-L-carnitine. Acetyl-L-carnitine (O-Acetyl-L-carnitine) is a compound involved in human metabolic research. It has relevant applications in predicting metabolite biomarker changes using the Recon 2 metabolic reconstruction model and integrating and analyzing multiple data types, but its specific activity mechanism is not described in detail based on the existing information .
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Cat. No.: HY-W131302
CAS No.: 5657-17-0
Synonyms: N,N-Ethylenediglycine
Target:  

Endogenous Metabolite

Research Areas:  

Cancer

Ethylenediaminediacetic acid (N,N-Ethylenediglycine) is an important ligand that enhances the antiproliferative activity of metal complexes. The complexes formed by ethylenediacetic acid and metal ions exhibited significant antiproliferative properties in MCF-7 cancer cell line. The metal complexes of ethylenediacetic acid were able to interact with DNA and were studied by CD and EPR spectroscopy techniques. Ethylenediaminediacetic acid and its metal complexes were able to induce cell cycle arrest at the G(0)/G(1) phase. The crystal structure analysis of ethylenediacetic acid provided important structural information for understanding its biological activity .
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Cat. No.: HY-P5158
CAS No.: 381725-58-2
Target:  

Adrenergic Receptor

Research Areas:  

Others

Conopeptide rho-TIA is a peptide derived from the venom contained in the predatory sea snail Conus tulipa, has highly selective and noncompetitive inhibitor at human α1B-Adrenergic Receptor. Conopeptide rho-TIA acts a competitive inhibitor at human α1A-Adrenergic Receptor and α1D-Adrenergic Receptor. Conopeptide rho-TIA binds to each subtype and may provide useful information for the development of novel α1-Adrenergic Receptor subtype-selective drugs .
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Cat. No.: HY-117747
CAS No.: 151867-81-1
Synonyms: JCR 424; XM 323
Target:  

HIV Protease

Research Areas:  

Infection

DMP 323 is a potent, nonpeptide cyclic urea inhibitor of HIV protease, effective against both HIV type 1 and type 2. Designed using structural information and database searching, it competitively inhibits the cleavage of both peptide and HIV-1 gag polyprotein substrates. DMP 323 shows comparable potency to other highly effective HIV protease inhibitors like A-80987 and Ro-31-8959. Importantly, its efficacy against HIV protease remains unaffected by human plasma or serum, suggesting low affinity for plasma proteins. Furthermore, DMP 323 demonstrates minimal inhibition of various mammalian proteases at concentrations much higher than those needed for HIV protease inhibition, highlighting its specificity for viral targets .
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Cat. No.: HY-122425
CAS No.: 447-41-6
Synonyms: Buphenine
Target:  

Others

Research Areas:  

Others

Nylidrin (Buphenine) is a compound in the form of hydrochloride. Its specific mechanism of activity and application details are not described in detail from the existing information.
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Cat. No.: HY-164556
CAS No.: 17434-81-0
Target:  

DNA/RNA Synthesis

Research Areas:  

Others

3′-Deoxy-5′-AMPIt can be used to study various physiological processes such as energy metabolism and information transmission.
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Cat. No.: HY-164556A
CAS No.: 71997-30-3
Target:  

DNA/RNA Synthesis

Research Areas:  

Others

3′-Deoxy-5′-AMP sodiumIt can be used to study various physiological processes such as energy metabolism and information transmission.
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Cat. No.: HY-138227
CAS No.: 13052-95-4
Synonyms: 3′-dADP
Target:  

DNA/RNA Synthesis

Research Areas:  

Others

3′-Deoxyadenosine 5′-diphosphate (3′-dADP)It can be used to study various physiological processes such as energy metabolism and information transmission.
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