381725-58-2
Chemical Structure
Conopeptide rho-TIA
- CAS No.: 381725-58-2
- Formula:C105H160N36O21S4
- Molecular Weight:2390.88
InChIKey: JOSBKXVAGAOPRY-WJKLNYSRSA-N
SMILES: O=C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CSSC[C@@](NC([C@@H](NC1=O)C)=O)([H])C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H]2CC3=CN=CN3)=O)CC(N)=O)=O)CCCNC(N)=N)=O)CCCNC(N)=N)=O)C(N[C@](CSSC[C@H](NC([C@@H](NC([C@@H](NC([C@@H](NC2=O)CCCCN)=O)CCCCN)=O)CC4=CC=CC=C4)=O)C(N)=O)([H])C(N[C@H](C(N[C@@](C(N5[C@@]1([H])CCC5)=O)([H])[C@@H](C)CC)=O)CC(C)C)=O)=O)=O)[C@@H](NC([C@H](CC(N)=O)NC([C@@H](N)CC6=CC=CC=C6)=O)=O)CC7=CNC8=CC=CC=C78
Biological Activity: Conopeptide rho-TIA is a peptide derived from the venom contained in the predatory sea snail Conus tulipa, has highly selective and noncompetitive inhibitor at human α1B-Adrenergic Receptor. Conopeptide rho-TIA acts a competitive inhibitor at human α1A-Adrenergic Receptor and α1D-Adrenergic Receptor. Conopeptide rho-TIA binds to each subtype and may provide useful information for the development of novel α1-Adrenergic Receptor subtype-selective drugs[1].
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Conopeptide rho-TIA | Conopeptide rho-TIA is a peptide derived from the venom contained in the predatory sea snail Conus tulipa, has highly selective and noncompetitive inhibitor at human α1B-Adrenergic Receptor. Conopeptide rho-TIA acts a competitive inhibitor at human α1A-Adrenergic Receptor and α1D-Adrenergic Receptor. Conopeptide rho-TIA binds to each subtype and may provide useful information for the development of novel α1-Adrenergic Receptor subtype-selective drugs. | |||||||||||||||||||||
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