952068-57-4
Chemical Structure
Parishin E
- CAS No.: 952068-57-4
- Formula:C19H24O13
- Molecular Weight:460.39
IUPAC Name: 2-hydroxy-2-(2-oxo-2-((4-(((2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)benzyl)oxy)ethyl)succinic acid
InChIKey: XAIUTKHLNZBMEG-HUNOYVTQSA-N
SMILES: O[C@H]([C@H]([C@@H]([C@@H](CO)O1)O)O)[C@@H]1OC2=CC=C(COC(CC(O)(C(O)=O)CC(O)=O)=O)C=C2
Biological Activity: Parishin E is a modulator of hexokinase 2, lactate dehydrogenase A, and silent information regulator 6 (sirtuin 6), and is also a component present in Gastrodia elata Blume[2]. Parishin E reduces the expression of hexokinase 2 and lactate dehydrogenase A, thereby regulating the process of cellular glycolysis[1]. Parishin E regulates the deacetylation mediated by silent information regulator 6 (Sirtuin 6), and inhibits histone 3 lactylation modifications at the H3K18la and H3K27la sites[1]. Parishin E inhibits macrophage polarization[1]. Parishin E alleviates LPS-induced inflammatory responses and suppresses the expression of pro-inflammatory cytokines[1]. Parishin E exerts ameliorating effects on rheumatoid arthritis[1]. Parishin E can be used in studies related to rheumatoid arthritis[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Parishin E | 98.90% | Parishin E is a modulator of hexokinase 2, lactate dehydrogenase A, and silent information regulator 6 (sirtuin 6), and is also a component present in Gastrodia elata Blume. Parishin E reduces the expression of hexokinase 2 and lactate dehydrogenase A, thereby regulating the process of cellular glycolysis. Parishin E regulates the deacetylation mediated by silent information regulator 6 (Sirtuin 6), and inhibits histone 3 lactylation modifications at the H3K18la and H3K27la sites. Parishin E inhibits macrophage polarization. Parishin E alleviates LPS-induced inflammatory responses and suppresses the expression of pro-inflammatory cytokines. Parishin E exerts ameliorating effects on rheumatoid arthritis. Parishin E can be used in studies related to rheumatoid arthritis. | ||||||||||||||||||||
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Parishin E (Standard) | ≥98% | Parishin E (Standard) is the analytical standard of Parishin E. This product is intended for research and analytical applications. Parishin E, a parishin derivative isolated from Gastrodia elata, may have antioxidant property. | ||||||||||||||||||||
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References
- [1]. Liu X, et al. Parishin E from ginger-processed Gastrodia elata Bl. alleviates rheumatoid arthritis by regulating histone 3 lactylation at H3K18la and H3K27la sites. Front Pharmacol. 2025 Oct 28;16:1682504. [Content Brief]
- [2]. Liu J, et al. An Optimized and Sensitive Pharmacokinetic Quantitative Method of Investigating Gastrodin, Parishin, and Parishin B, C and E in Beagle Dog Plasma using LC-MS/MS after Intragastric Administration of Tall Gastrodia Capsules. Molecules. 2017 Nov 10;22(11):1938. [Content Brief]
