SGK1-IN-5
Based on 1 Customer Validation
SGK1-IN-5 is a SGK1 inhibitor with an IC50 of 0.003 μM. SGK1-IN-5 can be used for the research of osteoarthritis, rheumatism.
For research use only. We do not sell to patients.
- CAS No.: 1426214-51-8
- Formula: C17H12Cl2N6O2S
- Molecular Weight:435.29
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Storage:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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SGK1 0.003 μM (IC50) |
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| U2OS | IC50 |
1.4 μM
Compound: 1
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Inhibition of recombinant human SGK1 (S61 to L431, S422D) expressed in human U20S cells assessed as inhibition of GSK3beta phosphorylation after 6 hrs by fluorescence assay
Inhibition of recombinant human SGK1 (S61 to L431, S422D) expressed in human U20S cells assessed as inhibition of GSK3beta phosphorylation after 6 hrs by fluorescence assay
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[PMID: 24900601] |
| U2OS | IC50 |
1.4 μM
Compound: 14g
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Inhibition of SGK1 in human U2OS cells assessed as phosphorylation of GSK3beta
Inhibition of SGK1 in human U2OS cells assessed as phosphorylation of GSK3beta
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[PMID: 25589934] |
SGK1-IN-5 (example 1) inhibits SGK-1 depenent phosphorylation of GSK3beta in U2OS cells, with an IC50 of 1.4 μM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 1426214-51-8
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Appearance Solid
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Molecular Weight 435.29
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Formula C17H12Cl2N6O2S
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SMILES
O=S(C1=CC=CC(Cl)=C1Cl)(NC2=CC=C(C3=CN=C4C(NN=C4N)=N3)C=C2)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Purity & Documentation
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Data Sheet (268 KB)
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SDS (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
SGK1-IN-5 Related Classifications
HY-128221 Related Classifications
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