(S)-Willardiine
Based on 1 Customer Validation
(S)-Willardiine ((-)-Willardiine) is a subtype-selective glutamate receptor agonist and the active isomer of Willardiine. Willardiine binds to and activates hGluR1, hGluR2, hGluR4 and hGluR5, with Ki values of 3.6 nM and 0.24 nM for hGluR4 and hGluR5, respectively. (S)-Willardiine is used to investigate the distribution and physiological functions of glutamate receptor subunits in the central nervous system.
For research use only. We do not sell to patients.
- Purity: 98.93%
- CAS No.: 21416-43-3
- Formula: C7H9N3O4
- Molecular Weight:199.17
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 2 years , -20°C, 1 year
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
All iGluR Isoforms
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Biological Activity
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AMPA Receptor |
Kainate Receptor |
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Cell Line
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Type | Value | Description | References |
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| Oocyte | EC50 |
11.5 μM
Compound: (S)-2a, (S)-willardiine
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Agonist activity at cyclothiazide-desensitized rat recombinant flop iGluR1 expressed in Xenopus laevis oocytes by two electrode voltage-clamp electrophysiology method
Agonist activity at cyclothiazide-desensitized rat recombinant flop iGluR1 expressed in Xenopus laevis oocytes by two electrode voltage-clamp electrophysiology method
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[PMID: 18811139] |
(S)-Willardiine (10-12-10-3 M; 60 min) binds with low affinity to homomeric hGluR1, hGluR2, and hGluR4 receptors, displaying the weakest potency among tested willardiine analogs on these human AMPA receptor subtypes[1].
(S)-Willardiine (10-12-10-3 M; 60 min) binds with very low affinity to homomeric hGluR5 receptors, displaying the weakest potency among tested willardiine analogs on this human kainate receptor subtype[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 21416-43-3
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Appearance Solid
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Molecular Weight 199.17
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Formula C7H9N3O4
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Color White to off-white
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SMILES
N[C@@H](CN(C(N1)=O)C=CC1=O)C(O)=O
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Synonyms
(-)-Willardiine
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 2 years -20°C 1 year
Solvent & Solubility
H2O : < 0.1 mg/mL (insoluble)
Purity & Documentation
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Data Sheet (270 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
(S)-Willardiine Related Classifications
HY-12499 Related Classifications
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