Antitumor agent-223
Antitumor agent-223 is an anticancer agent and TRK inhibitor. Antitumor agent-223 exerts potent antitumor activity against liver cancer and breast cancer. Antitumor agent-223 can be used for the research of hepatocellular carcinoma and breast cancer.
For research use only. We do not sell to patients.
- CAS No.: 3124621-78-6
- Formula: C24H22F4N4O
- Molecular Weight:458.45
-
Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biological Activity
-
Chemical Information
- Purity & Documentation
- References
-
Help & FAQs
Biological Activity
Antitumor agent-223 (Compound IIIc) potently inhibits the proliferation of HepG2 hepatocellular carcinoma cells (IC50 = 2.06 μM) and MCF-7 breast cancer cells (IC50 = 3.15 μM)[1].
Antitumor agent-223 (1-7 μM; 48-96 h) effectively inhibits the migration of HepG2 hepatocellular carcinoma cells in a concentration- and time-dependent manner, with a migration rate of 16.70% after treatment at 7 μM for 96 h[1].
Antitumor agent-223 (1-5 μM) potently reduces the colony-forming ability of HepG2 hepatocellular carcinoma cells, with a colony formation rate of 12.50% at 5 μM and 38.20% at 3 μM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Cell Line:HepG2 hepatocellular carcinoma cells
-
Concentration:1-5 μM (48 h, 96 h); 7 μM (96 h)
-
Incubation Time:48 h, 96 h
-
Result:Inhibits HepG2 cell migration in a concentration- and time-dependent manner.
Reduces the cell migration rate to 16.70% at 7 μM for 96 h (compared to the control group's 70.08%, P < 0.01).
Reduces migration rates relative to controls at 1 μM, 3 μM, and 5 μM at both 48 h and 96 h.
Chemical Information
-
CAS No. 3124621-78-6
-
Molecular Weight 458.45
-
Formula C24H22F4N4O
-
SMILES
O=C(N1)/C(C2=C1C=CC(NCC3=C(F)C=CC(C(F)(F)F)=C3)=C2)=C\C4=CN=C(CCCC)N4
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Antitumor agent-223 Related Classifications
HY-184729 Related Classifications
Powered by Bioz