EBOV-IN-11
EBOV-IN-11 is a protein phosphatase 1 (PP1) inhibitor, with Kd values of 1.88 nM and 8.01 nM against wild-type and quadruple-mutant PP1, respectively. EBOV-IN-11 potently inhibits the replication and transcription of EBOV-eGFP virus. EBOV-IN-11 can be used in studies related to Ebola virus infection.
For research use only. We do not sell to patients.
- CAS No.: 752216-12-9
- Formula: C26H25N3O6
- Molecular Weight:475.50
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
EBOV-IN-11 (Compound C31) (10 μM; 3 d) inhibits the replication of EBOV-eGFP in Vero E6 cells with low initial cytotoxicity[1].
EBOV-IN-11 (100 μM) exhibits <30% cytotoxicity in 293T cells, while it shows no cytotoxicity in PBMCs[1].
EBOV-IN-11 (1-30 μM; 49 h) potently inhibits EBOV replication in Vero E6 cells at concentrations of 3 μM and above, reducing viral titers by 2-3 orders of magnitude[1].
EBOV-IN-11 (10 μM; 48 h) inhibits the transcription of EBOV minigenome in 293T cells, with inhibitory potency comparable to that of 1E7-03[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 752216-12-9
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Molecular Weight 475.50
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Formula C26H25N3O6
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SMILES
O=C(OC(C(=O)NC(=O)N)C)C=1C=2C=CC=CC2N=C3C(=CC4=CC=C(OC)C(OC)=C4)CCC31
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
EBOV-IN-11 Related Classifications
HY-125258 Related Classifications
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