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DCUN1D1 - defective in cullin neddylation 1 domain containing 1 Gene

Also Known as RP42; SCRO; Tes3; DCNL1; SCCRO; DCUN1L1

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 54165

About DCUN1D1

Cytogenetic location: 3q26.33 Genomic coordinates (GRCh38): 3:182,938,074-182,985,918 (from NCBI)

This gene has 8 transcripts (splice variants), 217 orthologues and 4 paralogues. Broad expression in testis (RPKM 16.2), bone marrow (RPKM 6.8) and 24 other tissues.

Summary

Enables cullin family protein binding activity. Involved in positive regulation of protein neddylation and regulation of protein ubiquitination. Located in cytosol and nucleoplasm. Part of ubiquitin Ligase complex. [provided by Alliance of Genome Resources, Apr 2022]

DCUN1D1 Products (2)

mRNA	Protein	Name
NM_001308101.2	NP_001295030.1	DCN1-like protein 1 isoform 2
NM_020640.4	NP_065691.2	DCN1-like protein 1 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables cullin family protein binding	IMP IMP: Inferred from mutant phenotype	19617556	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	16189514	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in positive regulation of protein neddylation	IMP IMP: Inferred from mutant phenotype	23201271	GOA
involved in regulation of protein neddylation	IMP IMP: Inferred from mutant phenotype	19617556	GOA
involved in regulation of protein ubiquitination	IMP IMP: Inferred from mutant phenotype	23401859	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in cytoplasm	IMP IMP: Inferred from mutant phenotype	26906416	GOA
located in nucleus	IMP IMP: Inferred from mutant phenotype	26906416	GOA
part of ubiquitin ligase complex	IDA IDA: Inferred from direct assay	18826954	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

DCUN1D1 Protein Structure

UBA_4

Cullin_binding

0
100
200
259 a.a.

Protein Preferred Names	Protein Names
DCN1-like protein 1	DCN1, defective in cullin neddylation 1, domain containing 1

DCUN1D1 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	DCUN1D1	Q96GG9	TP53BP2	Homo sapiens	Q13625-3	Y2H Array	25416956
Intra	DCUN1D1	Q96GG9	TP53BP2	Homo sapiens	Q13625-3	Y2H Prey Pooling	25416956
Intra	DCUN1D1	Q96GG9	UBE2M	Homo sapiens	P61081	TAP	21145461
Intra	DCUN1D1	Q96GG9	UBE2M	Homo sapiens	P61081	Anti Tag CoIP	19617556
Intra	DCUN1D1	Q96GG9	ABRAXAS2	Homo sapiens	Q15018	Y2H Array	32296183
Intra	DCUN1D1	Q96GG9	ABRAXAS2	Homo sapiens	Q15018	Y2H Prey Pooling	32296183
Intra	DCUN1D1	Q96GG9	TRIM39	Homo sapiens	Q9HCM9-2	Validated Y2H	27107012
Intra	DCUN1D1	Q96GG9	TRIM39	Homo sapiens	Q9HCM9-2	Y2H Prey Pooling	32296183
Intra	DCUN1D1	Q96GG9	TRIM39	Homo sapiens	Q9HCM9-2	Validated Y2H	32296183
Intra	DCUN1D1	Q96GG9	TRIM39	Homo sapiens	Q9HCM9-2	BFG-2H	27107012
Intra	DCUN1D1	Q96GG9	TRIM39	Homo sapiens	Q9HCM9-2	Y2H Array	32296183
Intra	DCUN1D1	Q96GG9	TMEM239	Homo sapiens	Q8WW34-2	Y2H Prey Pooling	32296183
Intra	DCUN1D1	Q96GG9	TMEM239	Homo sapiens	Q8WW34-2	Y2H Array	32296183
Intra	DCUN1D1	Q96GG9	FAM168A	Homo sapiens	Q92567-2	Y2H Prey Pooling	32296183
Intra	DCUN1D1	Q96GG9	FAM168A	Homo sapiens	Q92567-2	Y2H Array	32296183
Intra	DCUN1D1	Q96GG9	TRIM54	Homo sapiens	Q9BYV2	Y2H Prey Pooling	25416956
Intra	DCUN1D1	Q96GG9	TRIM54	Homo sapiens	Q9BYV2	Y2H Array	25416956
Intra	DCUN1D1	Q96GG9	TRIM54	Homo sapiens	Q9BYV2	Validated Y2H	25416956
Intra	DCUN1D1	Q96GG9	TRIM8	Homo sapiens	Q9BZR9	Y2H Prey Pooling	32296183
Intra	DCUN1D1	Q96GG9	TRIM8	Homo sapiens	Q9BZR9	Y2H Array	32296183
Intra	DCUN1D1	Q96GG9	TRIM8	Homo sapiens	Q9BZR9	Validated Y2H	32296183
Intra	DCUN1D1	Q96GG9	SUSD6	Homo sapiens	Q92537	Y2H Array	32296183
Intra	DCUN1D1	Q96GG9	SUSD6	Homo sapiens	Q92537	Y2H Prey Pooling	32296183
Intra	DCUN1D1	Q96GG9	ARRDC3	Homo sapiens	Q96B67	Y2H Array	32296183
Intra	DCUN1D1	Q96GG9	ARRDC3	Homo sapiens	Q96B67	Y2H Prey Pooling	32296183
Intra	DCUN1D1	Q96GG9	ARRDC3	Homo sapiens	Q96B67	Validated Y2H	25416956
Intra	DCUN1D1	Q96GG9	CDIP1	Homo sapiens	Q9H305	Validated Y2H	32296183
Intra	DCUN1D1	Q96GG9	CDIP1	Homo sapiens	Q9H305	Y2H Array	32296183
Intra	DCUN1D1	Q96GG9	CDIP1	Homo sapiens	Q9H305	Y2H Prey Pooling	32296183
Intra	DCUN1D1	Q96GG9	PLEKHB2	Homo sapiens	Q96CS7	Y2H Array	32296183
Intra	DCUN1D1	Q96GG9	PLEKHB2	Homo sapiens	Q96CS7	Y2H Prey Pooling	32296183
Intra	DCUN1D1	Q96GG9	DAZAP2	Homo sapiens	Q15038	Validated Y2H	25416956
Intra	DCUN1D1	Q96GG9	DAZAP2	Homo sapiens	Q15038	Y2H Array	25416956
Intra	DCUN1D1	Q96GG9	DAZAP2	Homo sapiens	Q15038	Y2H Array	32296183
Intra	DCUN1D1	Q96GG9	DAZAP2	Homo sapiens	Q15038	Y2H Prey Pooling	32296183
Intra	DCUN1D1	Q96GG9	TRIM39	Homo sapiens	Q9HCM9	Y2H Pooling	16189514
Intra	DCUN1D1	Q96GG9	TRIM39	Homo sapiens	Q9HCM9	Y2H Array	25416956
Intra	DCUN1D1	Q96GG9	LZTS2	Homo sapiens	Q9BRK4	Y2H Array	32296183
Intra	DCUN1D1	Q96GG9	LZTS2	Homo sapiens	Q9BRK4	Y2H Prey Pooling	32296183
Intra	DCUN1D1	Q96GG9	LZTS2	Homo sapiens	Q9BRK4	Validated Y2H	32296183
Intra	DCUN1D1	Q96GG9	LZTS2	Homo sapiens	Q9BRK4	Y2H Array	25416956
Intra	DCUN1D1	Q96GG9	GMPPA	Homo sapiens	Q96IJ6	Y2H Prey Pooling	32296183
Intra	DCUN1D1	Q96GG9	GMPPA	Homo sapiens	Q96IJ6	Validated Y2H	32296183
Intra	DCUN1D1	Q96GG9	GMPPA	Homo sapiens	Q96IJ6	Y2H Array	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant DCUN1D1 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P70093	DCN1-like protein 1/DCUN1D1 Protein, Human (His)	Q96GG9 (M1-V259)	≥ 95%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases	Alias
Squamous Cell Carcinoma	Epidermoid Carcinoma Squamous Cell Cancer Carcinoma, Squamous Cell Squamous Cell Skin Cancer Malignant Squamous Cell Tumor Squamous Carcinoma Squamous Cell Epithelioma Carcinoma Squamous Cell Neoplasms, Squamous Cell Squamous Cell Carcinoma - Category Malignant Squamous Cell Neoplasm Squamous Cell Carcinoma Of Skin
Scrotum Squamous Cell Carcinoma	Squamous Cell Carcinoma Of Scrotum Scrotal Squamous Cell Carcinoma
Scrotal Carcinoma	Carcinoma Of Scrotum Malignant Neoplasm Of Scrotum Neoplasm Of Scrotum

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS03598	DCUN1D1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS19277	Dcun1d1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS25767	Dcun1d1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	DCUN1D1	VGNC	VGNC:102688
Rattus norvegicus	DCUN1D1	RGD	RGD:1309668
Canis familiaris	DCUN1D1	VGNC	VGNC:39822
Bos taurus	DCUN1D1	VGNC	VGNC:27935
Mus musculus	DCUN1D1	MGD	MGI:2150386
Macaca mulatta	DCUN1D1	VGNC	VGNC:84194
Others	DCUN1D1	NCBI