SphK2-IN-5
SphK2-IN-5 is a selective SphK2 inhibitor with an IC50 of 0.55 μM. SphK2-IN-5 exhibits anticancer activity against colon cancer and liver cancer.
For research use only. We do not sell to patients.
- Formula: C20H15N3O5S
- Molecular Weight:409.42
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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SphK2 0.55 μM (IC50) |
SphK2-IN-5 (Compound 6a) potently and selectively inhibits SphK2 with an IC50 of 0.55 μM; it shows negligible activity against SphK1 at a concentration of 10 μM[1].
SphK2-IN-5 (48 h) exhibits potent and selective antiproliferative activity against the HCT-116, MC38, Hepa1-6 and HepG2 tumor cell lines, and shows no activity against non-tumorigenic NIH-3T3 cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:MCF-7, HCT-116, MC38, Hepa1-6, HepG2, NIH-3T3
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Concentration:Different concentrations
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Incubation Time:48 h
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Result:Showed IC50s of >100 μM, 10.43 μM, 1.45 μM, 9.57 μM, 0.23 μM, >100 μM for MCF-7, HCT-116, MC38, Hepa1-6, HepG2, NIH-3T3, respectively.
Chemical Information
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Molecular Weight 409.42
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Formula C20H15N3O5S
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SMILES
O=C(NC/1=O)SC1=C\C2=CN(CCOC3=CC=C([N+]([O-])=O)C=C3)C4=C2C=CC=C4
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
SphK2-IN-5 Related Classifications
HY-184272 Related Classifications
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