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EGFR-IN-62

EGFR-IN-62 (compound 9h) is a potent and reversible EGFR kinase inhibitor, with IC50 values of 10 nM (L858R/T790 M), 29 nM (WT), and 242 nM (L858R/T790 M/C797S), respectively. EGFR-IN-62 shows antiproliferative activity against A549 and H1975 cell lines, with IC50 values of 2.53 and 1.56 μM, respectively. EGFR-IN-62 induces dose-dependent apoptosis process, G1/G0-phase arrestation, and the inhibition of motility on A549 and/or H1975 cell lines.

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  • CAS No.: 2890261-65-9
  • Formula: C30H33N9O2
  • Molecular Weight:551.64
  • Storage:

    Please store the product under the recommended conditions in the Certificate of Analysis.

  • EGFR-IN-62 Chemical Structure
    EGFR-IN-62 Chemical Structure
CAS No.: 2890261-65-9
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  • EGFR-IN-62 Chemical Structure
    EGFR-IN-62 Chemical Structure
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  • EGFR-IN-62