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ELOVL6-IN-2 

Cat. No.: HY-12146 Purity: 99.02%
Handling Instructions

ELOVL6-IN-2 is a potent, orally active and selective ELOVL6 inhibition. ELOVL6-IN-2 inhibits mouse ELOVL6 activities, with IC50 value of 34 nM.

For research use only. We do not sell to patients.

ELOVL6-IN-2 Chemical Structure

ELOVL6-IN-2 Chemical Structure

CAS No. : 1067647-43-1

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Free Sample (0.5-1 mg)   Apply Now  
Solution
10 mM * 1 mL in DMSO USD 89 In-stock
Estimated Time of Arrival: December 31
Solid + Solvent
10 mM * 1 mL
ready for reconstitution
USD 89 In-stock
Estimated Time of Arrival: December 31
Solid
5 mg USD 70 In-stock
Estimated Time of Arrival: December 31
10 mg USD 120 In-stock
Estimated Time of Arrival: December 31
25 mg USD 250 In-stock
Estimated Time of Arrival: December 31
50 mg USD 450 In-stock
Estimated Time of Arrival: December 31
100 mg USD 750 In-stock
Estimated Time of Arrival: December 31
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Based on 1 publication(s) in Google Scholar

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Description

ELOVL6-IN-2 is a potent, orally active and selective ELOVL6 inhibition. ELOVL6-IN-2 inhibits mouse ELOVL6 activities, with IC50 value of 34 nM[1].

IC50 & Target

IC50: 34 nM (ELOVL6)[1]

In Vivo

ELOVL6-IN-2 (0.1~1mg/kg; p.o.; 2 hours) potently and dose-proportionally suppresses the elongation index in the liver[1].
ELOVL6-IN-2 (10mg/kg; p.o.; 2 hours) demonstrates to be highly liver penetrable[1].
ELOVL6-IN-2 (1mg/kg; p.o.; 2~24 hours) exhibits sustained plasma exposure[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male C57BL/6J mice
Dosage: 0.1~1mg/kg
Administration: P.o; 2 hours
Result: Potently and dose-proportionally suppressed the elongation index in the liver.
Animal Model: Male C57BL/6J mice
Dosage: 10 mg/kg
Administration: P.o; 2 hours
Result: Demonstrated to be highly liver penetrable.
Animal Model: Male C57BL/6J mice
Dosage: 1 mg/kg
Administration: P.o; 2~24 hours
Result: Exhibited sustained plasma exposure.
Molecular Weight

579.49

Formula

C₂₈H₂₃F₆N₃O₄

CAS No.
SMILES

O=C1N(C2=CC=CC=C2)C3=C(C(CC(C)(C)C3)=O)C1(C4=C(C)NN(C5=CC=C(OC(F)(F)F)C=C5)C4=O)C(F)(F)F

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (172.57 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.7257 mL 8.6283 mL 17.2566 mL
5 mM 0.3451 mL 1.7257 mL 3.4513 mL
10 mM 0.1726 mL 0.8628 mL 1.7257 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: 2.5 mg/mL (4.31 mM); Suspended solution; Need ultrasonic

  • 2.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (4.31 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Keywords:

ELOVL6-IN-2Otherspotentorallyselectivedose-proportionallyplasmaliverInhibitorinhibitorinhibit

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Product Name:
ELOVL6-IN-2
Cat. No.:
HY-12146
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