1. JAK/STAT Signaling
    Protein Tyrosine Kinase/RTK
  2. EGFR
  3. EMI1

EMI1 

Cat. No.: HY-138072
Handling Instructions

EMI1 is an EGFR ex19del/T790M/C797S and EGFR L858R/T790M/C797S inhibitor. EMI1 can be used for the research of mutant EGFR-associated, drug-resistant non-small-cell lung cancer (NSCLC).

For research use only. We do not sell to patients.

EMI1 Chemical Structure

EMI1 Chemical Structure

CAS No. : 35773-42-3

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Description

EMI1 is an EGFR ex19del/T790M/C797S and EGFR L858R/T790M/C797S inhibitor. EMI1 can be used for the research of mutant EGFR-associated, drug-resistant non-small-cell lung cancer (NSCLC)[1].

IC50 & Target[1]

EGFRdel19 T790M C797S

 

EGFRL858R/T790M/C797S

 

In Vitro

EMI1 inhibits PC9 EGFR ex19del/T790M/C797S organoid growth with the EC50 of 131 nM[1].
EMI1 (1 nM-10 μM) potently reduces the interaction of EGFR triple mutant with Shc1[1].
EMI1 (1 nM-100μM) strongly inhibits the viability and increase the caspase 3/7 activity of PC9 EGFR ex19del/T790M/C797S triple-mutant cells than noncancerous human bronchial epithelial (HBE) cells[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay[1]

Cell Line: PC9 EGFR ex19del/T790M/C797S and HBE bronchial epithelial lung EGFR-WT control cells.
Concentration: 0.001, 0.01, 0.1, 1, 10, 100 μM
Incubation Time: 72 hours
Result: Strongly inhibited the viability.
Molecular Weight

334.37

Formula

C₂₀H₁₈N₂O₃

CAS No.

35773-42-3

SMILES

O=C1C(C2=NC3=CC=CC=C3O2)=CC4=CC=C(N(CC)CC)C=C4O1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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Keywords:

EMI1EMI 1EMI-1EGFREpidermal growth factor receptorErbB-1HER1triplemutant,ex19delT790MC797SL858RInhibitorinhibitorinhibit

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