1. Anti-infection
  2. HIV
  3. Emivirine

Emivirine (Synonyms: MKC-442)

Cat. No.: HY-15353
Handling Instructions

Emivirine (MKC-442) is a non-nucleoside reverse transcriptase inhibitors (NNRTIs) with Ki values of 0.20 and 0.01 μM for dTTP- and dGTP-dependent DNA or RNA polymerase activity, respectively. Emivirine displays potent and selective anti-human immunodeficiency virus type 1 (HIV-1) activity.

For research use only. We do not sell to patients.

Emivirine Chemical Structure

Emivirine Chemical Structure

CAS No. : 149950-60-7

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Description

Emivirine (MKC-442) is a non-nucleoside reverse transcriptase inhibitors (NNRTIs) with Ki values of 0.20 and 0.01 μM for dTTP- and dGTP-dependent DNA or RNA polymerase activity, respectively. Emivirine displays potent and selective anti-human immunodeficiency virus type 1 (HIV-1) activity[1][2].

In Vitro

Emivirine (EMV) is also specific for HIV-1 RT and was without effect on HIV-2[2].
Emivirine (EMV) has no obvious toxicity for human healthy cells[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay[2]

Cell Line: Human bone marrow cells collected from normal healthy volunteers.
Concentration: 0, 0.1, 1, 10, or 100 μM.
Incubation Time: 14 days.
Result: At concentrations of 0.1 to 10 μM, no effect on cell growth, lactic acid production, mitochondrial DNA synthesis, or mitochondrial structure was seen compared to what occurred with untreated HepG2 cells.
In Vivo

Tthe approximate lethal oral dose of Emivirine (EMV) for rats was ≥3 g/kg for males and 2.5 g/kg for females[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male Sprague-Dawley rats[2].
Dosage: 50 mg/kg.
Administration: Gavage.
Result: The oral absorption was 68%.
Molecular Weight

302.37

Formula

C₁₇H₂₂N₂O₃

CAS No.
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Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Emivirine
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HY-15353
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