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NUP54 - nucleoporin 54 Gene

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 53371

About NUP54

Cytogenetic location: 4q21.1 Genomic coordinates (GRCh38): 4:76,114,664-76,148,397 (from NCBI)

This gene has 29 transcripts (splice variants) and 197 orthologues. Ubiquitous expression in bone marrow (RPKM 12.3), testis (RPKM 11.6) and 25 other tissues.

Summary

The nuclear envelope creates distinct nuclear and cytoplasmic compartments in eukaryotic cells. It consists of two concentric membranes perforated by nuclear pores, large protein complexes that form aqueous channels to regulate the flow of macromolecules between the nucleus and the cytoplasm. These complexes are composed of at least 100 different polypeptide subunits, many of which belong to the nucleoporin family. This gene encodes a member of the phe-gly (FG) repeat-containing nucleoporin subset. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jun 2013]

NUP54 Products (2)

mRNA	Protein	Name
NM_001278603.2	NP_001265532.1	nucleoporin p54 isoform 2
NM_017426.4	NP_059122.2	nucleoporin p54 isoform 1

Gene Ontology

Molecular Function
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	16189514	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in nuclear envelope	IDA IDA: Inferred from direct assay	24315095	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

NUP54 Protein Structure

Nup54

0
100
200
300
400
507 a.a.

Protein Preferred Names	Protein Names
nucleoporin p54	54 kDa nucleoporin

NUP54 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	NUP54	Q7Z3B4	ZWINT	Homo sapiens	O95229	Y2H Prey Pooling	32296183
Intra	NUP54	Q7Z3B4	ZWINT	Homo sapiens	O95229	Y2H Array	32296183
Intra	NUP54	Q7Z3B4	CENPH	Homo sapiens	Q9H3R5	Y2H Prey Pooling	32296183
Intra	NUP54	Q7Z3B4	CENPH	Homo sapiens	Q9H3R5	Validated Y2H	32296183
Intra	NUP54	Q7Z3B4	CCHCR1	Homo sapiens	Q8TD31-3	Validated Y2H	32296183
Intra	NUP54	Q7Z3B4	TEKT1	Homo sapiens	Q969V4	Y2H Prey Pooling	32296183
Intra	NUP54	Q7Z3B4	TEKT1	Homo sapiens	Q969V4	Validated Y2H	32296183
Intra	NUP54	Q7Z3B4	TEKT1	Homo sapiens	Q969V4	Y2H Array	32296183
Intra	NUP54	Q7Z3B4	NFKBID	Homo sapiens	Q8NI38	Y2H Prey Pooling	32296183
Intra	NUP54	Q7Z3B4	NFKBID	Homo sapiens	Q8NI38	Validated Y2H	32296183
Intra	NUP54	Q7Z3B4	NFKBID	Homo sapiens	Q8NI38	Y2H Array	32296183
Intra	NUP54	Q7Z3B4	EXOC1	Homo sapiens	Q9NV70	Validated Y2H	32296183
Intra	NUP54	Q7Z3B4	EXOC1	Homo sapiens	Q9NV70	Anti Tag CoIP	33961781
Intra	NUP54	Q7Z3B4	KRT33B	Homo sapiens	Q14525	Y2H Array	32296183
Intra	NUP54	Q7Z3B4	KRT33B	Homo sapiens	Q14525	Y2H Prey Pooling	32296183
Intra	NUP54	Q7Z3B4	AP2B1	Homo sapiens	P63010-2	Y2H Prey Pooling	32296183
Intra	NUP54	Q7Z3B4	AP2B1	Homo sapiens	P63010-2	Y2H Array	32296183
Intra	NUP54	Q7Z3B4	AP1B1	Homo sapiens	Q10567-3	Y2H Array	32296183
Intra	NUP54	Q7Z3B4	AP1B1	Homo sapiens	Q10567-3	Y2H Prey Pooling	32296183
Intra	NUP54	Q7Z3B4	TEX12	Homo sapiens	Q9BXU0	Validated Y2H	32296183
Intra	NUP54	Q7Z3B4	TEX12	Homo sapiens	Q9BXU0	Y2H Array	32296183
Intra	NUP54	Q7Z3B4	TEX12	Homo sapiens	Q9BXU0	Y2H Prey Pooling	32296183
Intra	NUP54	Q7Z3B4	DCTN3	Homo sapiens	O75935-2	Y2H Prey Pooling	32296183
Intra	NUP54	Q7Z3B4	DCTN3	Homo sapiens	O75935-2	Y2H Array	32296183
Intra	NUP54	Q7Z3B4	SOHLH1	Homo sapiens	Q5JUK2	Y2H Prey Pooling	32296183
Intra	NUP54	Q7Z3B4	SOHLH1	Homo sapiens	Q5JUK2	Y2H Array	32296183
Intra	NUP54	Q7Z3B4	EURL	Homo sapiens	Q9NYK6-3	Y2H Prey Pooling	32296183
Intra	NUP54	Q7Z3B4	EURL	Homo sapiens	Q9NYK6-3	Validated Y2H	32296183
Intra	NUP54	Q7Z3B4	EURL	Homo sapiens	Q9NYK6-3	Y2H Array	32296183
Cross	NUP54	Q7Z3B4	P0DTD1-PRO_0000449627	SARS-CoV-2	P0DTD1-PRO_0000449627	Y2H Array	36217030
Intra	NUP54	Q7Z3B4	TACC3	Homo sapiens	Q9Y6A5	Validated Y2H	32296183
Intra	NUP54	Q7Z3B4	TACC3	Homo sapiens	Q9Y6A5	Y2H Array	32296183
Intra	NUP54	Q7Z3B4	TACC3	Homo sapiens	Q9Y6A5	Y2H Prey Pooling	32296183
Intra	NUP54	Q7Z3B4	HAUS8	Homo sapiens	Q9BT25	Y2H Prey Pooling	32296183
Intra	NUP54	Q7Z3B4	HAUS8	Homo sapiens	Q9BT25	Validated Y2H	32296183
Intra	NUP54	Q7Z3B4	HAUS8	Homo sapiens	Q9BT25	Y2H Array	32296183
Intra	NUP54	Q7Z3B4	PKNOX2	Homo sapiens	Q96KN3	Validated Y2H	32296183
Intra	NUP54	Q7Z3B4	PKNOX2	Homo sapiens	Q96KN3	Y2H Array	32296183
Intra	NUP54	Q7Z3B4	PKNOX2	Homo sapiens	Q96KN3	Y2H Prey Pooling	32296183
Intra	NUP54	Q7Z3B4	NUP58	Homo sapiens	Q9BVL2	Anti Tag CoIP	33961781
Intra	NUP54	Q7Z3B4	NUP58	Homo sapiens	Q9BVL2	Validated Y2H	32296183
Intra	NUP54	Q7Z3B4	NUP58	Homo sapiens	Q9BVL2	Crosslink	30021884
Intra	NUP54	Q7Z3B4	KRT27	Homo sapiens	Q7Z3Y8	Validated Y2H	32296183
Intra	NUP54	Q7Z3B4	KRT27	Homo sapiens	Q7Z3Y8	Y2H Array	32296183
Intra	NUP54	Q7Z3B4	KRT27	Homo sapiens	Q7Z3Y8	Y2H Prey Pooling	32296183
Intra	NUP54	Q7Z3B4	SMYD3	Homo sapiens	Q9H7B4	Y2H Array	32296183
Intra	NUP54	Q7Z3B4	SMYD3	Homo sapiens	Q9H7B4	Y2H Prey Pooling	32296183
Intra	NUP54	Q7Z3B4	SMYD3	Homo sapiens	Q9H7B4	Validated Y2H	32296183
Intra	NUP54	Q7Z3B4	NUP62	Homo sapiens	P37198	Validated Y2H	25416956
Intra	NUP54	Q7Z3B4	NUP62	Homo sapiens	P37198	Y2H Array	25416956
Intra	NUP54	Q7Z3B4	NUP62	Homo sapiens	P37198	Anti Tag CoIP	33961781
Intra	NUP54	Q7Z3B4	NUP62	Homo sapiens	P37198	Y2H Array	27194810
Intra	NUP54	Q7Z3B4	NUP62	Homo sapiens	P37198	Y2H Array	32296183
Intra	NUP54	Q7Z3B4	NUP62	Homo sapiens	P37198	Y2H Prey Pooling	32296183
Intra	NUP54	Q7Z3B4	TPM3	Homo sapiens	P06753	Y2H Prey Pooling	32296183
Intra	NUP54	Q7Z3B4	TPM3	Homo sapiens	P06753	Y2H Array	32296183
Intra	NUP54	Q7Z3B4	CDC23	Homo sapiens	Q9UJX2	Validated Y2H	32296183
Intra	NUP54	Q7Z3B4	OIP5	Homo sapiens	O43482	Y2H Prey Pooling	32296183
Intra	NUP54	Q7Z3B4	OIP5	Homo sapiens	O43482	Y2H Array	32296183
Intra	NUP54	Q7Z3B4	EIF3F	Homo sapiens	O00303	Y2H Prey Pooling	32296183
Intra	NUP54	Q7Z3B4	EIF3F	Homo sapiens	O00303	Y2H Array	32296183
Intra	NUP54	Q7Z3B4	AGR2	Homo sapiens	O95994	Y2H Prey Pooling	32296183
Intra	NUP54	Q7Z3B4	AGR2	Homo sapiens	O95994	Y2H Array	32296183
Intra	NUP54	Q7Z3B4	C14orf119	Homo sapiens	Q9NWQ9	Validated Y2H	32296183
Intra	NUP54	Q7Z3B4	HGS	Homo sapiens	O14964	Y2H Array	25416956
Intra	NUP54	Q7Z3B4	HGS	Homo sapiens	O14964	Y2H Prey Pooling	25416956
Intra	NUP54	Q7Z3B4	HGS	Homo sapiens	O14964	Validated Y2H	25416956
Intra	NUP54	Q7Z3B4	TCHP	Homo sapiens	Q9BT92	Validated Y2H	32296183
Intra	NUP54	Q7Z3B4	EXOC8	Homo sapiens	Q8IYI6	Validated Y2H	32296183
Intra	NUP54	Q7Z3B4	SPG21	Homo sapiens	Q9NZD8	Validated Y2H	32296183
Intra	NUP54	Q7Z3B4	IFT20	Homo sapiens	Q8IY31	Validated Y2H	25416956
Intra	NUP54	Q7Z3B4	HOMER1	Homo sapiens	Q86YM7	Anti Tag CoIP	33961781
Intra	NUP54	Q7Z3B4	HOMER1	Homo sapiens	Q86YM7	Validated Y2H	32296183
Intra	NUP54	Q7Z3B4	HOMER1	Homo sapiens	Q86YM7	Y2H Array	32296183
Intra	NUP54	Q7Z3B4	HOMER1	Homo sapiens	Q86YM7	Y2H Prey Pooling	32296183
Intra	NUP54	Q7Z3B4	SERTAD3	Homo sapiens	Q9UJW9	Y2H Prey Pooling	32296183
Intra	NUP54	Q7Z3B4	SERTAD3	Homo sapiens	Q9UJW9	Validated Y2H	32296183
Intra	NUP54	Q7Z3B4	SERTAD3	Homo sapiens	Q9UJW9	Y2H Array	32296183
Intra	NUP54	Q7Z3B4	AIRIM	Homo sapiens	Q9NX04	Validated Y2H	32296183
Intra	NUP54	Q7Z3B4	IFT20	Homo sapiens	Q8IY31-3	Validated Y2H	32296183
Intra	NUP54	Q7Z3B4	IFT20	Homo sapiens	Q8IY31-3	Y2H Array	32296183
Intra	NUP54	Q7Z3B4	IFT20	Homo sapiens	Q8IY31-3	Y2H Prey Pooling	32296183
Intra	NUP54	Q7Z3B4	BPIFA1	Homo sapiens	Q9NP55	Y2H Prey Pooling	32296183
Intra	NUP54	Q7Z3B4	BPIFA1	Homo sapiens	Q9NP55	Validated Y2H	32296183
Intra	NUP54	Q7Z3B4	BPIFA1	Homo sapiens	Q9NP55	Y2H Array	32296183
Cross	NUP54	Q7Z3B4	PA	Influenza A virus	Q67020	Pull Down	21994455

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS09696	NUP54 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	NUP54	VGNC	VGNC:78542
Canis familiaris	NUP54	VGNC	VGNC:44057
Rattus norvegicus	NUP54	RGD	RGD:619926
Mus musculus	NUP54	MGD	MGI:1920460
Macaca mulatta	NUP54	VGNC	VGNC:75420
Others	NUP54	NCBI