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Cat. No.: HY-115273

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MRS-2179

2 Cited Publications

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Based on 2 publication(s) in Google Scholar

MRS-2179 is a selective and competitive antagonist for P2Y1 receptor, with K_B of 0.177 μM.

For research use only. We do not sell to patients.

CAS No.: 101204-49-3
Formula: C₁₁H₁₇N₅O₉P₂
Molecular Weight:425.23

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (272 KB)

MRS-2179 Chemical Structure

CAS No.: 101204-49-3

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- Cellular Effect
Chemical Information
Publications (2)
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

MRS-2179 is a selective and competitive antagonist for P2Y1 receptor, with K_B of 0.177 μM^[1].

IC₅₀ & Target

P2Y1 Receptor

All P2Y Receptor Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
COS-7	IC₅₀	210 nM Compound: MRS-2179	Inhibition concentration required against wild type strain P2Y1 receptor expressed in COS-7 cells is determined using [3H]-MRS2279 as radioligand Inhibition concentration required against wild type strain P2Y1 receptor expressed in COS-7 cells is determined using [3H]-MRS2279 as radioligand	[PMID: 15481977]
COS-7	IC₅₀	320 nM Compound: MRS-2179	Inhibition concentration required against human Y306A mutant strain P2Y1 receptor expressed in COS-7 cells is determined using [3H]MRS2279 as radioligand Inhibition concentration required against human Y306A mutant strain P2Y1 receptor expressed in COS-7 cells is determined using [3H]MRS2279 as radioligand	[PMID: 15481977]
COS-7	IC₅₀	330 nM Compound: MRS-2179	Inhibition concentration required against human Y203F mutant strain P2Y1 receptor expressed in COS-7 cells is determined using [3H]MRS2279 as radioligand Inhibition concentration required against human Y203F mutant strain P2Y1 receptor expressed in COS-7 cells is determined using [3H]MRS2279 as radioligand	[PMID: 15481977]
COS-7	IC₅₀	480 nM Compound: MRS-2179	Inhibition concentration required against human Y273A mutant strain P2Y1 receptor expressed in COS-7 cells is determined using [3H]-MRS2279 as radioligand Inhibition concentration required against human Y273A mutant strain P2Y1 receptor expressed in COS-7 cells is determined using [3H]-MRS2279 as radioligand	[PMID: 15481977]
COS-7	IC₅₀	660 nM Compound: MRS-2179	Inhibition concentration required against human Y273F mutant strain P2Y1 receptor expressed in COS-7 cells is determined using [3H]MRS2279 as radioligand Inhibition concentration required against human Y273F mutant strain P2Y1 receptor expressed in COS-7 cells is determined using [3H]MRS2279 as radioligand	[PMID: 15481977]
COS-7	IC₅₀	740 nM Compound: MRS-2179	Inhibition concentration required against human Y203A (EL2) mutant strain P2Y1 receptor expressed in COS-7 cells is determined using [3H]MRS2279 as radioligand Inhibition concentration required against human Y203A (EL2) mutant strain P2Y1 receptor expressed in COS-7 cells is determined using [3H]MRS2279 as radioligand	[PMID: 15481977]
COS-7	IC₅₀	980 nM Compound: MRS-2179	Inhibition concentration required against human Y306F mutant strain P2Y1 receptor expressed in COS-7 cells is determined using [3H]MRS2279 as radioligand Inhibition concentration required against human Y306F mutant strain P2Y1 receptor expressed in COS-7 cells is determined using [3H]MRS2279 as radioligand	[PMID: 15481977]
Oocyte	EC₅₀	>10000 nM Compound: MRS-2179	Antagonist activity against recombinant rat receptor P2X purinoceptor 2 (P2X2) at 10 uM, expressed in Xenopus oocytes Antagonist activity against recombinant rat receptor P2X purinoceptor 2 (P2X2) at 10 uM, expressed in Xenopus oocytes	[PMID: 12213051]
Oocyte	EC₅₀	>10000 nM Compound: MRS-2179	Antagonist activity against recombinant rat P2X purinoceptor 4 (P2X4) at 3 uM, expressed in Xenopus oocytes Antagonist activity against recombinant rat P2X purinoceptor 4 (P2X4) at 3 uM, expressed in Xenopus oocytes	[PMID: 12213051]
Oocyte	EC₅₀	13 μM Compound: MRS-2179	The compound was evaluated for antagonist activity against recombinant rat P2X purinoceptor 3 (P2X3) at 30 uM, expressed in Xenopus oocytes The compound was evaluated for antagonist activity against recombinant rat P2X purinoceptor 3 (P2X3) at 30 uM, expressed in Xenopus oocytes	[PMID: 12213051]

Chemical Information

CAS No. 101204-49-3
Molecular Weight 425.23
Formula C₁₁H₁₇N₅O₉P₂
SMILES

CNC1=C2C(N([C@@H]3O[C@H](CO[P](O)(O)=O)[C@@H](O[P](O)(O)=O)C3)C=N2)=NC=N1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Publications (2)

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Journal Impact Factor

Mil Med Res

PANX1-mediated ATP release confers FAM3A's suppression effects on hepatic gluconeogenesis and lipogenesis. [Abstract]

2024 Jun 27;11(1):41. PMID: 38937853
Int J Biol Macromol

Sibanin, a novel black fly-derived Kunitz protease inhibitor, prevents thrombus formation in mice by anticoagulation-antiplatelet duality. [Abstract]

2025 Mar:296:139766. PMID: 39800030

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (272 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Moro S, et al., Human P2Y1 receptor: molecular modeling and site-directed mutagenesis as tools to identify agonist and antagonist recognition sites. J Med Chem. 1998 Apr 23;41(9):1456-66. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Biological Activity
- Description
- IC₅₀ & Target
Chemical Information
Publications (2)
Purity & Documentation
References

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MRS-2179

Publications Citing Use of MedChemExpress (MCE) MRS-2179

All P2Y Receptor Isoforms