USP14 - ubiquitin specific peptidase 14 Gene

Also Known as TGT; Ubp6

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 9097

About USP14

Cytogenetic location: 18p11.32 Genomic coordinates (GRCh38): 18:158,557-214,629 (from NCBI)

This gene has 9 transcripts (splice variants), 217 orthologues, 71 paralogues and is associated with 1 phenotype. Ubiquitous expression in brain (RPKM 16.7), prostate (RPKM 15.4) and 25 other tissues.

Summary

This gene encodes a member of the ubiquitin-specific processing (UBP) family of proteases that is a deubiquitinating enzyme (DUB) with His and Cys domains. This protein is located in the cytoplasm and cleaves the ubiquitin moiety from ubiquitin-fused precursors and ubiquitinylated proteins. Mice with a mutation that results in reduced expression of the ortholog of this protein are retarded for growth, develop severe tremors by 2 to 3 weeks of age followed by hindlimb paralysis and death by 6 to 10 weeks of age. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]

USP14 Products (2)

mRNA	Protein	Name
NM_001037334.2	NP_001032411.1	ubiquitin carboxyl-terminal hydrolase 14 isoform b
NM_005151.4	NP_005142.1	ubiquitin carboxyl-terminal hydrolase 14 isoform a

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Referencias	Source
enables K63-linked deubiquitinase activity	EXP EXP: Inferred from Experiment	26620909	GOA
enables cysteine-type deubiquitinase activity	IDA IDA: Inferred from direct assay	19106094	GOA
enables deubiquitinase activity	IMP IMP: Inferred from mutant phenotype	19135427	GOA
enables endopeptidase inhibitor activity	IMP IMP: Inferred from mutant phenotype	18162577	GOA
enables proteasome binding	IDA IDA: Inferred from direct assay	18162577	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	19106094	GOA

Biological Process GO Annotation	Evidence	Referencias	Source
involved in negative regulation of ERAD pathway	IMP IMP: Inferred from mutant phenotype	19135427	GOA
involved in negative regulation of ubiquitin-dependent protein catabolic process	IMP IMP: Inferred from mutant phenotype	19135427	GOA
involved in protein K48-linked deubiquitination	IMP IMP: Inferred from mutant phenotype	18162577	GOA
involved in regulation of chemotaxis	IMP IMP: Inferred from mutant phenotype	19106094	GOA
involved in regulation of proteasomal protein catabolic process	IMP IMP: Inferred from mutant phenotype	18162577	GOA

Cellular Component GO Annotation	Evidence	Referencias	Source
located in cell surface	IDA IDA: Inferred from direct assay	19106094	GOA
is active in cytoplasm	IDA IDA: Inferred from direct assay	27666593	GOA
located in cytoplasmic vesicle	IDA IDA: Inferred from direct assay	19106094	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

USP14 Protein Structure

UCH

0
100
200
300
400
494 a.a.

Protein Preferred Names	Protein Names
ubiquitin carboxyl-terminal hydrolase 14	deubiquitinating enzyme 14

USP14 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Referencias
Intra	USP14	P54578	PPP3CA	Homo sapiens	Q08209	IF	19896943
Intra	USP14	P54578	PPP3CA	Homo sapiens	Q08209	Anti Tag CoIP	19896943

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant USP14 Proteins

Referencia número	Nombre del producto	Accession	Pureza
HY-P71418	USP14 Protein, Human (His)	P54578-1 (D91-Q494)	≥ 90%, as determined by reducing SDS-PAGE.

USP14 Antibodies

Referencia número	Nombre del producto	Aplicación	Reactivity
HY-P83583	PMS2 Antibody (YA3328)	WB, ICC/IF, FC	Human, Mouse, Rat

Related Diseases

Diseases	Alias
Autosomal Dominant Cerebellar Ataxia	Spinocerebellar Ataxia Adca Pierre Marie Cerebellar Ataxia Ataxia, Spinocerebellar Sca Autosomal Dominant Spinocerebellar Ataxia Spinocerebellar Ataxias
Microcephaly	Microencephaly Microcephalus Microcephalic Nanocephaly Congenital Microcephaly Brain Hypoplasia Brain Nondevelopment Cephalic Hypoplasia Undeveloped Cerebrum Undeveloped Brain Micrencephalon Micrencephaly

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (15)

Referencia número	Nombre del producto	Efecto	Pureza	Rare Diseases
HY-13264	Degrasyn		99.70%	Unkown
HY-13817	IU1		99.30%	Unkown
HY-13989	b-AP15		98.05%	Unkown
HY-122243	IU1-47	Inhibitor	99.87%	Unkown
HY-122885	IU1-248	Inhibitor	99.19%	Unkown
HY-D1236	Fluorescent brightener 71	Inhibitor	/	Unkown
HY-135779	IU2-6	Inhibitor	/	Unkown
HY-164689	Cadmium pyrithione	Inhibitor	/	Unkown
HY-176207	HDAC degrader-1	Degrader	/	Unkown
HY-181495	RAJQ14	Degrader	/	Unkown
HY-187197	GL-637	Inhibitor	/	Unkown
HY-RS15525	USP14 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-15432	(E/Z)-NSC-687852		/	Unkown
HY-RS16634	Usp14 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS23069	Usp14 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	USP14	VGNC	VGNC:48179
Rattus norvegicus	USP14	RGD	RGD:1311825
Felis catus	USP14	VGNC	VGNC:66868
Bos taurus	USP14	VGNC	VGNC:36712
Macaca mulatta	USP14	VGNC	VGNC:78736
Mus musculus	USP14	MGD	MGI:1928898
Others	USP14	NCBI