EST73502
EST73502 is a selective, orally active and blood-brain barrier (BBB) penetrant dual μ-opioid receptor (MOR) agonist and σ1 receptor (σ1R) antagonist, with Kis of 64 nM and 118 nM for MOR and σ1R, respectively. EST73502 has antinociceptive activity.
For research use only. We do not sell to patients.
- CAS No.: 1838622-25-5
- Formula: C19H26F2N2O2
- Molecular Weight:352.42
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Ki: 64 nM (MOR), 118 nM (σ1R)[1]
EST73502 (5 mg/kg; i.p.; twice a day; for 10 days) attenuates partial sciatic nerve ligation (PSNL)-induced mechanical allodynia in male CD1 mice[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Male CD1 mice, PSNL model[1]
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Dosage:5 mg/kg
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Administration:Intraperitoneal injection, twice a day, for 10 days
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Result:Attenuated the expression of mechanical allodynia induced by PSNL, reaching a maximal effect of 56%.
Chemical Information
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CAS No. 1838622-25-5
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Molecular Weight 352.42
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Formula C19H26F2N2O2
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SMILES
FC1=CC=C(F)C=C1CCN(CC2)CCC2(O[C@@H]3C)CN(CC)C3=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
EST73502 Related Classifications
HY-134189 Related Classifications
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