2. Apoptosis Cytoskeleton Cell Cycle/DNA Damage
  3. Apoptosis Microtubule/Tubulin
  4. Estramustine phosphate

Estramustine phosphate, an estradiol analog, is an orally active antimicrotubule chemotherapy agent. Estramustine phosphate depolymerises microtubules by binding to microtubule associated proteins (MAPs) and/or to tubulin. Estramustine phosphate can interfere mitosis, trigger cell death and induce apoptosis, which can be used for the research of cancer like prostate cancer.

For research use only. We do not sell to patients.

Estramustine phosphate Chemical Structure

Estramustine phosphate Chemical Structure

CAS No. : 4891-15-0

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Estramustine phosphate Related Antibodies

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Description

Estramustine phosphate, an estradiol analog, is an orally active antimicrotubule chemotherapy agent. Estramustine phosphate depolymerises microtubules by binding to microtubule associated proteins (MAPs) and/or to tubulin. Estramustine phosphate can interfere mitosis, trigger cell death and induce apoptosis, which can be used for the research of cancer like prostate cancer[1][2][3].

In Vitro

Estramustine phosphate (1 µg/mL, 48 h) suppresses PC3 cell growth[1].
Estramustine phosphate (2 µg/mL, 48 h) elevates phosphatidylserine eversion amount on PC3 cells and induces PC3 cell apoptosis through reducing miR-31[1].
Estramustine phosphate (0-40 µM, 24-72 h) inhibits cell proliferation and tubulin cytoskeleton in RAW 264.7 cells[2].
Estramustine phosphate (10 µM, 24 h) inhibits TGF-β-induced RAW 264.7 cell migration, as well as TGF-β-induced uPA production by inhibiting Smad3 activation[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Estramustine phosphate Related Antibodies

Cell Viability Assay[1]

Cell Line: PC3 cells
Concentration: 1 µg/ mL
Incubation Time: 48 h
Result: Suppressed PC3 cell growth.

Immunofluorescence[2]

Cell Line: RAW 264.7 cells
Concentration: 10 µM
Incubation Time: 24 h
Result: Disrupted the interphase microtubules.

Cell Migration Assay [2]

Cell Line: 18 h of TGF-β treated RAW 264.7 cells
Concentration: 10 µM
Incubation Time: 24 h
Result: Inhibited TGF-β-Induced Cell Migration.
In Vivo

Estramustine phosphate (Intraperitoneal injection, 4 or 12 mg/kg, a daily dose for 2 weeks) inhibits PAC120 tumor growth 53% by day 35[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Human prostate cancer xenograft PAC120[3]
Dosage: 4 or 12 mg/kg, a daily dose for 2 weeks.
Administration: Intraperitoneal injection
Result: Inhibited PAC120 tumor growth 53% by day 35.
Clinical Trial
Molecular Weight

520.38

Formula

C23H32Cl2NO6P
CAS No.
SMILES

O=C(OC1=CC=C2[C@@]3([H])CC[C@]4(C)[C@@H](OP(O)(O)=O)CC[C@@]4([H])[C@]3([H])CCC2=C1)N(CCCl)CCCl
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Estramustine phosphate Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Estramustine4891-15-0ApoptosisMicrotubule/TubulinAntimicrotubuleprostate cancerantitumourMiR-31microtubule (MT) cytoskeletontransforming growth factor-βantimitoticInhibitorinhibitorinhibit

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