1. Membrane Transporter/Ion Channel
    Neuronal Signaling
  2. GABA Receptor
  3. FG 7142

FG 7142 (Synonyms: ZK 39106; LSU-65)

Cat. No.: HY-100991 Purity: >99.0%
Handling Instructions

FG 7142 (ZK 39106; LSU-65), a non-selectively benzodiazepine inverse agonist, has high affinity for the α1 subunit-containing GABAA receptor (Ki=91 nM). FG 7142 (ZK 39106; LSU-65) also modulates GABA-induced chloride flux at GABAA receptors expressing the α1 subunit (EC50= 137 nM). FG 7142 (ZK 39106; LSU-65) can increase tyrosine hydroxylation and cause upregulation of β-adrenoceptors in mouse cerebral cortex.

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FG 7142 Chemical Structure

FG 7142 Chemical Structure

CAS No. : 78538-74-6

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 75 In-stock
Estimated Time of Arrival: December 31
2 mg USD 60 In-stock
Estimated Time of Arrival: December 31
5 mg USD 120 In-stock
Estimated Time of Arrival: December 31
10 mg USD 200 In-stock
Estimated Time of Arrival: December 31
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Based on 1 publication(s) in Google Scholar

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Description

FG 7142 (ZK 39106; LSU-65), a non-selectively benzodiazepine inverse agonist, has high affinity for the α1 subunit-containing GABAA receptor (Ki=91 nM). FG 7142 (ZK 39106; LSU-65) also modulates GABA-induced chloride flux at GABAA receptors expressing the α1 subunit (EC50= 137 nM). FG 7142 (ZK 39106; LSU-65) can increase tyrosine hydroxylation and cause upregulation of β-adrenoceptors in mouse cerebral cortex[1].

IC50 & Target

Ki: 91 nM (GABAA receptor)[1]

In Vitro

FG-7142 has affinity for those expressing the α subunit, the Ki values are 91 nM; 330 nM; 492 nM and 2.150 μM for α1, α2,α3 and α5 subunits, respectively[1].
FG-7142 has a high efficacy in modulating GABA-induced chloride flux at GABAA receptors expressing the α1 subunit (EC50 = 137 nM) as compared to the other α subunits (EC50: α2= 507 nM,α3=1.021μM , α5=1.439 μM)[1].

In Vivo

FG-7142 (intraperitoneal injection; 15-30 mg/kg) activates mesolimbocortical dopaminergic projections, leading to increases in dopamine in the prefrontal cortex and the nucleus accumbens in rats[1].
FG-7142 (intraperitoneal injection; 15 mg/kg) increases tyrosine hydroxylase activity and dopamine turnover in the medial prefrontal cortex and ventral tegmentum in vivo, but effects are not detected in mesolimbic or nigrostriatal areas[1].

Molecular Weight

225.25

Formula

C₁₃H₁₁N₃O

CAS No.

78538-74-6

SMILES

O=C(C1=CC2=C(C=N1)NC3=C2C=CC=C3)NC

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
References

Purity: >99.0%

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Keywords:

FG 7142ZK 39106LSU-65FG7142FG-7142ZK39106ZK-39106LSU65LSU 65GABA ReceptorGamma-aminobutyric acid Receptorγ-Aminobutyric acid Receptorinverse agonistdopaminergic tyrosine hydroxylasenucleus accumbenGABAA receptorInhibitorinhibitorinhibit

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FG 7142
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HY-100991
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