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Cat. No.: HY-12384

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Tenosal

Tenosal is a new compound obtained by esterifying salicylic acid with 2-thiophene-carboxylic acid and displays anti-inflammatory, analgesic and antipyretic properties.

For research use only. We do not sell to patients.

CAS No.: 95232-68-1
Formula: C₁₂H₈O₄S
Molecular Weight:248.25

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (273 KB)

Tenosal Chemical Structure

CAS No.: 95232-68-1

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vivo
Chemical Information
Protocol
Purity & Documentation
References
Calculators
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Biological Activity

Description

Tenosal is a new compound obtained by esterifying salicylic acid with 2-thiophene-carboxylic acid and displays anti-inflammatory, analgesic and antipyretic properties.

All COX Isoforms :

In Vivo

Tenosal is a new compound obtained by esterifying salicylic acid with 2-thiophene-carboxylic acid and displays anti-inflammatory, analgesic and antipyretic properties. Extraction recovery measured is on average 95.75% for Tenosal, 98.71% for salicylic acid (SA) and 91.11% for TA. In the whole analysis of Tenosal extracted from plasma, the inter-assay coefficient of variation (C.V.) ranges from 1.00 to 5.86% and the intra assay C.V. is 5.01%. The administration of Tenosal allows a higher bioavailability of SA to be achieved than after dosing with ASA^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 95232-68-1
Molecular Weight 248.25
Formula C₁₂H₈O₄S
SMILES

O=C(C1=CC=CS1)OC2=CC=CC=C2C(O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Protocol

Animal Administration^[1]

Both sexes of albino Sprague-Dawley rats (175 to 200 g body weight) are used for the experiment. Before the trial the animals are caged for seven days at 21 to 22°C and 55 to 75% relative humidity with a cycle of 12 h light-12 h dark. The animals are orally treated with Tenosal (300 mg/kg) or ASA (220 mg/kg) by a gastric gavage, both substances being suspended in 2% arabic gum. Six animals per group are killed at times 0 (baseline), 0.5, 1, 2, 4, 8, 16 and 24 h. Heparinized blood is sampled and centrifuged to obtain plasma. Liver, kidneys, lungs, myocardium, gastric wall and intestinal wall are also sampled from the animals killed 0, 1, 2, 4, 8 and 16 h after dosing. All the samples are stored in a freezer at -20°C^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (273 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Lucarelli C, et al. Evaluation of 2-(2-thiophenecarboxy)benzoic acid and related active metabolites in biological samples. J Chromatogr. 1992 Jan 3;573(1):150-3. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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