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Allo-aca TFA

10 Cited Publications
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Based on 10 publication(s) in Google Scholar

Allo-aca TFA, a leptin peptidomimetic, is a potent, specific leptin receptor antagonist peptide. Allo-aca TFA blocks leptin signaling and action in numerous in vitro and in vivo models.

For research use only. We do not sell to patients.

  • Formula: C50H76F3N13O17
  • Molecular Weight:1188.21
  • Storage:

    Please store the product under the recommended conditions in the Certificate of Analysis.

  • Allo-aca TFA Chemical Structure
    Allo-aca TFA Chemical Structure
  • Experimental Validation Results for Allo-aca TFA
  • Experimental Validation Results for Allo-aca TFA
  • Experimental Validation Results for Allo-aca TFA
  • Experimental Validation Results for Allo-aca TFA
  • Experimental Validation Results for Allo-aca TFA
  • Experimental Validation Results for Allo-aca TFA
  • Experimental Validation Results for Allo-aca TFA
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To place orders, for customer services and technical support, please contact:

609-228-6898
[email protected] [email protected]
Find Your Local Distributor Your local distributor: Hycultec GmbHHycultec
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Histological Imaging/StainingFlow CytometryIn Vivo Efficacy StudyWBCell Proliferation/Viability AssayBio/Physico-chemical Assay
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  • In Vivo Efficacy Study
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  • Allo-aca TFA Chemical Structure
    Allo-aca TFA Chemical Structure
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    Allo-aca TFA purchased from MedChemExpress. Usage Cited in: Cancer Cell. 2026 Mar 9;44(3):658-675.e12. [Abstract]

    Customer Validation
     KMplots and BLI analysis of the mice received chemotherapy along with Veh. or Allo-aca (1 mg/kg; i.p.; every two days) (n = 8 mice/group).

  • 1/16

    Allo-aca TFA purchased from MedChemExpress. Usage Cited in: Cell Death Dis. 2026 Feb 23;17(1):249. [Abstract]

    Customer Validation
     Allo-aca (1 mg/kg; i.p.; once daily from days 11 to 20). Kaplan-Meier survival curve of MLL-AF9 AML mice (n = 5 mice per group).

  • 1/16

    Allo-aca TFA purchased from MedChemExpress. Usage Cited in: Cell Death Dis. 2026 Feb 23;17(1):249. [Abstract]

    Customer Validation
     Representative H&E-stained sections of BM, spleen and liver (scale bars: 20 μm). The results showed that leptin (Allo-aca) (1 mg/kg; i.p.; once daily from days 11 to 20) dampened Ara-C cytotoxicity, extensive leukemic infiltration of liver and spleen.

  • 1/16

    Allo-aca TFA purchased from MedChemExpress. Usage Cited in: Cell Death Dis. 2026 Feb 23;17(1):249. [Abstract]

    Customer Validation
     Allo-aca (1 mg/kg; i.p.; once daily from days 11 to 20). Representative FCM profiles (left) and quantification of YFP+ AML cells in BM, spleen, and liver of MLL-AF9 AML mice (n = 5 mice per group).

  • 1/16

    Allo-aca TFA purchased from MedChemExpress. Usage Cited in: Cell Death Dis. 2026 Feb 23;17(1):249. [Abstract]

    Customer Validation
     Western blot analysis of LEPR expression in AML cells under indicated treatments (Allo-aca (1 mg/kg; i.p.; once daily from days 11 to 20), ect.). β-actin served as the loading control.

  • 1/16

    Allo-aca TFA purchased from MedChemExpress. Usage Cited in: Cell Death Dis. 2026 Feb 23;17(1):249. [Abstract]

    Customer Validation
     Effect of Allo-aca on AML cell chemosensitivity by CCK-8 assay. The inhibition rates were calculated from eight treatment arms: (i) PBS; (ii) Allo-aca (1 mg/kg; i.p.; once daily from days 11 to 20) alone; (iii) Leptin alone; (iv) Allo-aca + Leptin; (v) Ara-C alone (or DNR); (vi) Allo-aca + Ara-C (or DNR); (vii) Leptin + Ara-C (or DNR) and (viii) Allo-aca + Leptin + Ara-C (or DNR).

  • 1/16

    Allo-aca TFA purchased from MedChemExpress. Usage Cited in: Cell Death Dis. 2026 Feb 23;17(1):249. [Abstract]

    Customer Validation
     Allo-aca (1 mg/kg; i.p.; once daily from days 11 to 20). Mitochondrial respiration analysis of sorted MLL-AF9 AML cells using Seahorse XF technology (n = 5 mice per group).

  • Allo-aca TFA