GYPC - glycophorin C (Gerbich blood group) Gene

Also Known as GE; GPC; GPD; GYPD; CD236; PAS-2; CD236R; PAS-2'

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 2995

About GYPC

Cytogenetic location: 2q14.3 Genomic coordinates (GRCh38): 2:126,656,158-126,696,667 (from NCBI)

This gene has 5 transcripts (splice variants), 136 orthologues and is associated with 3 phenotypes. Broad expression in bone marrow (RPKM 63.1), fat (RPKM 47.2) and 17 other tissues.

Summary

Glycophorin C (GYPC) is an integral membrane glycoprotein. It is a minor species carried by human erythrocytes, but plays an important role in regulating the mechanical stability of red cells. A number of glycophorin C mutations have been described. The Gerbich and Yus phenotypes are due to deletion of exon 3 and 2, respectively. The Webb and Duch antigens, also known as glycophorin D, result from single point mutations of the glycophorin C gene. The glycophorin C protein has very little homology with glycophorins A and B. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Feb 2012]

GYPC Products (3)

mRNA	Protein	Name
NM_001256584.2	NP_001243513.1	glycophorin-C isoform 3
NM_002101.5	NP_002092.1	glycophorin-C isoform 1
NM_016815.4	NP_058131.1	glycophorin-C isoform 2

Gene Ontology

Molecular Function
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	16669616	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in cortical cytoskeleton	IDA IDA: Inferred from direct assay	16669616	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
glycophorin-C	Gerbich blood group antigen

GYPC Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	GYPC	P04921	PLPPR2	Homo sapiens	Q96GM1	Validated Y2H	32296183
Intra	GYPC	P04921	PLPPR2	Homo sapiens	Q96GM1	Y2H Array	32296183
Intra	GYPC	P04921	PLPPR2	Homo sapiens	Q96GM1	Y2H Prey Pooling	32296183
Intra	GYPC	P04921	AQP6	Homo sapiens	Q13520	Y2H Prey Pooling	32296183
Intra	GYPC	P04921	AQP6	Homo sapiens	Q13520	Validated Y2H	32296183
Intra	GYPC	P04921	AQP6	Homo sapiens	Q13520	Y2H Array	32296183
Intra	GYPC	P04921	TMEM88	Homo sapiens	Q6PEY1	Y2H Prey Pooling	32296183
Intra	GYPC	P04921	TMEM88	Homo sapiens	Q6PEY1	Validated Y2H	32296183
Intra	GYPC	P04921	TMEM88	Homo sapiens	Q6PEY1	Y2H Array	32296183
Intra	GYPC	P04921	SHISAL1	Homo sapiens	Q3SXP7	Validated Y2H	32296183
Intra	GYPC	P04921	SHISAL1	Homo sapiens	Q3SXP7	Y2H Prey Pooling	32296183
Intra	GYPC	P04921	SHISAL1	Homo sapiens	Q3SXP7	Y2H Array	32296183
Intra	GYPC	P04921	GPR42	Homo sapiens	O15529	Y2H Prey Pooling	32296183
Intra	GYPC	P04921	GPR42	Homo sapiens	O15529	Y2H Array	32296183
Intra	GYPC	P04921	SLC10A6	Homo sapiens	Q3KNW5	Validated Y2H	32296183
Intra	GYPC	P04921	SLC10A6	Homo sapiens	Q3KNW5	Y2H Prey Pooling	32296183
Intra	GYPC	P04921	SLC10A6	Homo sapiens	Q3KNW5	Y2H Array	32296183
Intra	GYPC	P04921	ABHD16A	Homo sapiens	O95870	Y2H Prey Pooling	32296183
Intra	GYPC	P04921	ABHD16A	Homo sapiens	O95870	Y2H Array	32296183
Intra	GYPC	P04921	TSPAN15	Homo sapiens	O95858	Y2H Array	32296183
Intra	GYPC	P04921	TSPAN15	Homo sapiens	O95858	Y2H Prey Pooling	32296183
Intra	GYPC	P04921	TMEM14B	Homo sapiens	Q9NUH8	Y2H Array	32296183
Intra	GYPC	P04921	TMEM14B	Homo sapiens	Q9NUH8	Validated Y2H	32296183
Intra	GYPC	P04921	TMEM14B	Homo sapiens	Q9NUH8	Y2H Prey Pooling	32296183
Intra	GYPC	P04921	RHBDD1	Homo sapiens	Q8TEB9	Validated Y2H	32296183
Intra	GYPC	P04921	RHBDD1	Homo sapiens	Q8TEB9	Y2H Prey Pooling	32296183
Intra	GYPC	P04921	RHBDD1	Homo sapiens	Q8TEB9	Y2H Array	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant GYPC Proteins

Cat. No.	Product Name	Accession	Purity
HY-P76956	Glycophorin C/GYPC Protein, Human (HEK293, His)	P04921 (M1-M57)	≥ 95%, as determined by reducing SDS-PAGE.

GYPC Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P81411	Glycophorin C Antibody (YA1156)	IHC-P	Human
HY-P81411A	Glycophorin C Antibody (YA1156)(PBS only)	IHC-P	Human

Related Diseases

Diseases	Alias
Blood Group, Gerbich System	GE Gerbich Blood Group System
Malaria	Malaria, Susceptibility To Malaria, Resistance To Malaria, Cerebral Cerebral Malaria Malaria, Severe, Susceptibility To Malaria, Severe, Resistance To Malaria, Cerebral, Susceptibility To Induced Malaria Malaria, Vivax, Protection Against Malaria, Severe Malaria, Cerebral, Reduced Risk Of Malaria, Protection Against Resistance To Malaria Due To G6pd Deficiency Malaria Due To G6pd Deficiency Malarial Encephalitis CM Malaria Cerebral Susceptibility To Malaria Acute Pernicious Fever Aestivo-Autumnal Fever Aestivo Autumnal Malaria Chagres Fever Continued Malaria Fever Estivo-Autumnal Fever Estivo-Autumnal Malaria Estivo-Autumnal Malarial Fever Falciparum Fever Malignant Tertian Fever Malignant Tertian Malaria Pernicious Intermittent Fever Pernicious Malaria Quotidian Malaria Subtertian Fever Subtertian Malaria Fever Subtertian Malignant Tertian Malaria Tropical Malaria Algid Malaria Bilious Haemoglobinuric Fever Black Water Fever Blackwater Fever Malarial Blackwater Fever Severe Malarial Falciparum West African Fever Malarial Haematinuria Haemoglobinuric Fever Haemoglobinuric Malaria Severe Plasmodium Falciparum Malaria Malarial Haemoglobinuria Malarial Haematuria Falciparum Malaria [Malignant Tertian] Malaria Tropica Malarial Shock Chagres Virus Disease Malignant Malaria Mtm - [Malignant Tertian Malaria] Tm -[Malignant Tertian Malaria] Panama Fever St - [Subtertian Malaria] Malarial Quotidian Benign Tertian Malaria Tertian Ague Vivax Fever Plasmodium Vivax Malaria Nos Btm - [Benign Tertian Malaria] Bt - [Benign Tertian Malaria] Vivax Malaria Benign Tertian Vivax Malaria Tertian Malaria Quartan Malaria Quartan Ague Quartan Fever Plasmodium Malariae Malaria Nos Quartan Malarial Malaria By Plasmodium Malariae Malariae Malaria Ovale Tertian Malaria Plasmodium Ovale Fever Malaria Fever By Plasmodium Ovale Ovale Malaria Malaria By Plasmodium Ovale Malarial Ovale Marsh Fever Remittent Congestive Fever Coastal Fever Remittent Gastric Fever Miasmatic Fever Congestive Remittent Fever Intermittent Fever Jungle Fever Paludism Cameroon Fever Ague Corsican Fever Intermittent Bilious Fever Disease Due To Plasmodiidae Malarial Fever Plasmodiosis Remittent Fever Roman Fever Malaria Fever Nos Malaria Nos Paludal Fever Clinically Diagnosed Malaria Clinically Diagnosed Malaria Without Parasitological Confirmation Congestive Fever Malarial Cachexia Marsh Cachexia Paludal Cachexia Recurrent Malaria Remittent Malaria
Hereditary Elliptocytosis	Congenital Elliptocytosis Ovalocytosis Elliptocytosis, Hereditary He Elliptocytosis Hereditary Congenital Ovalocytosis Elliptocytosis Hereditary Elliptocytosis With Infantile Poikilocytosis Hereditary Ovalocytosis Oval Erythrocytosis He - [Hereditary Elliptocytosis] Elliptocytosis Anaemia
Chickenpox	Varicella Varicella Nos
Laryngotracheitis
Upper Lip Cancer
Herpes Simplex	Herpes Simplex Infections Herpesvirus Hominis Disease Herpes Simplex Disease Herpesviral Infection Due To Herpes Simplex Infections Due To Simplex Virus Herpes Nos
Viral Labyrinthitis	Epidemic Vertigo Vestibular Neuronitis
Herpes Zoster	Shingles Zoster Herpes Zona Herpes Zoster Disease Zona Zoster Herpes Zoster Of Skin And Mucous Membranes Zoster Nos Zoster With Nervous System Involvement
Dehydrated Hereditary Stomatocytosis 1 With Or Without Pseudohyperkalemia And/Or Perinatal Edema	Dehydrated Hereditary Stomatocytosis Hereditary Xerocytosis Xerocytosis, Hereditary Pshk1 Pseudohyperkalemia Edinburgh Dehydrated Hereditary Stomatocytosis With Or Without Pseudohyperkalemia And/Or Perinatal Edema DHS1 Dhs Hereditary Desiccytosis Dehydrated Hereditary Stomatocytosis 1 Desiccytosis, Hereditary Pseudohyperkalemia, Familial, 1, Due To Red Cell Leak Pseudohyperkalemia Familial 1, Due To Red Cell Leak Desiccytosis Hereditary Xerocytosis Hereditary Familial Pseudohyperkalemia 1 Due To Red Cell Leak Stomatocytosis, Dehydrated, Hereditary, With/Without Pseudohyperkalemia And/Or Perinatal Edema Xerocytosis
Acute Retinal Necrosis Syndrome	Acute Retinal Necrosis Retinal Necrosis Syndrome, Acute
Genital Herpes	Herpes Genitalis Genital Herpes Simplex Venereal Herpes Virus-Genital Herpes
Herpes Simplex Virus Keratitis	Dendritic Keratitis Keratitis, Dendritic Keratitis, Herpetic
Fetal Erythroblastosis	Erythroblastosis, Fetal Ef - Erythroblastosis Foetalis Erythroblastosis Fetalis Haemolytic Disease Due To Rhesus Isoimmunisation Rhesus Isoimmunisation Of The Newborn
Argentine Hemorrhagic Fever	Argentinian Hemorrhagic Fever Junin Hemorrhagic Fever Hemorrhagic Fever, Argentinian Ahf - [Argentinian Haemorrhagic Fever] Argentine Haemorrhagic Fever Junin Haemorrhagic Fever
Human Cytomegalovirus Infection	Cytomegalovirus Infection Cytomegalovirus Infections
Lassa Fever	Lf Lassa Hemorrhagic Fever Lf - [Lassa Fever]
Hereditary Spherocytosis	Congenital Spherocytic Hemolytic Anemia Spherocytic Anemia Congenital Spherocytosis Spherocytosis, Type 1 Minkowski Chauffard Syndrome Hs Minkowski-Chauffard Disease Minkowski-Chauffard Syndrome Spherocytosis Hereditary Spherocytosis, Hereditary Anemia, Hereditary Spherocytic Hemolytic
Herpetic Whitlow	Herpetic Felon
Plasmodium Vivax Malaria	Malaria, Vivax Malaria By Plasmodium Vivax Vivax Malaria Malaria Vivax
Labyrinthitis	Labyrinthine Disorder Inner Ear Inflammation Otitis Interna Labyrinth Hyperaemia

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS05934	GYPC Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS19338	Gypc Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS25829	Gypc Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	GYPC	MGD	MGI:1098566
Bos taurus	GYPC	VGNC	VGNC:49062
Rattus norvegicus	GYPC	RGD	RGD:1310295
Others	GYPC	NCBI