1-Naphthol
Based on 1 Customer Validation
1-naphthol (Furro ER) is an excited state proton transfer (ESPT) fluorescent molecular probe. 1-naphthol can sense the hydrophobic domains in micellar aggregation and accurately sense the sol-gel transition. 1-naphthol can be used to study the thermally induced microenvironmental changes and hydration levels of Pluronic F127 (PF127) in different microenvironments in aqueous media.
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- Pureza: 99.90%
- No. CAS: 90-15-3
- Fòrmula: C10H8O
- Peso molecular:144.17
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Almacenamiento:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 2 years , -20°C, 1 year
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Actividad biológica
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Chemical Information
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Solvente y solubilidad
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Actividad biológica
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| BXPC-3 | ED50 |
82 μM
Compound: 1-Naphthol
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Cytotoxicity against human BXPC-3 cells assessed as cell index incubated for 72 hrs by xCELLigence real time cell analyser method
Cytotoxicity against human BXPC-3 cells assessed as cell index incubated for 72 hrs by xCELLigence real time cell analyser method
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[PMID: 38903945] |
| HEK293 | IC50 |
240 μM
Compound: 1-Naphthol
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Inhibition of human recombinant UGT1A1 expressed in HEK293 cells assessed as reduction in bilirubin glucuronidation by LC-MS/MS method
Inhibition of human recombinant UGT1A1 expressed in HEK293 cells assessed as reduction in bilirubin glucuronidation by LC-MS/MS method
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[PMID: 21030469] |
| HEK293 | IC50 |
280 μM
Compound: 1-Naphthol
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Inhibition of human recombinant UGT1A1 expressed in HEK293 cells assessed as reduction in estradiol 3-glucuronidation by LC-MS/MS method
Inhibition of human recombinant UGT1A1 expressed in HEK293 cells assessed as reduction in estradiol 3-glucuronidation by LC-MS/MS method
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[PMID: 21030469] |
| K562 | IC50 |
>100 μM
Compound: 1-Naphthol
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Cytotoxicity in human K562 cells assessed as reduction in cell viability incubated for 72 hrs by cell-QB reagent based assay
Cytotoxicity in human K562 cells assessed as reduction in cell viability incubated for 72 hrs by cell-QB reagent based assay
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[PMID: 30199251] |
| RBL-1 | IC50 |
3.6 μM
Compound: 1
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Ability to inhibit 5-lipoxygenase by using a crude preparation of the cytosolic enzyme from the rat basophilic leukemia (RBL-1) cell line
Ability to inhibit 5-lipoxygenase by using a crude preparation of the cytosolic enzyme from the rat basophilic leukemia (RBL-1) cell line
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[PMID: 2104936] |
The ESPT kinetics of 1-Naphthol are sensitive to the availability of proton-accepting waters around the probe microenvironment, which is reflected in the fluorescence decay kinetics of the different protonated forms of the probe. The fluorescence lifetimes of excited anionic and neutral forms of 1-Naphthol allow for direct monitoring of the hydration level in the microenvironment[1].
1-Naphthol is distributed in all domains of the system: bulk aqueous phase, interfaces, and hydrophobic dry core, and the probe can fully sense all domains. In addition to the usual fluorescence intensity and spectral shifts, the lifetime parameter set of the two protonated forms also plays an important role[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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No. CAS 90-15-3
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Appearance Solid
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Peso molecular 144.17
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Fòrmula C10H8O
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Color White to off-white
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SMILES
OC1=C2C=CC=CC2=CC=C1
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Synonyms
Furro ER; NSC 9586; Nako TRB
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Structure Classification
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Initial Source
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Powder -20°C 3 years 4°C 2 years In solvent -80°C 2 years -20°C 1 year
Solvente y solubilidad
Ethanol : 100 mg/mL (693.63 mM; Need ultrasonic)
H2O : 1 mg/mL (6.94 mM; Need ultrasonic)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Pureza y Documentación
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Ficha de datos (277 KB)
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SDS (952 KB)
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Instrucciones de manejo (2659 KB)
Referencias
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O / Ethanol | 1 mM | 6.9363 mL | 34.6813 mL | 69.3626 mL | 173.4064 mL |
| 5 mM | 1.3873 mL | 6.9363 mL | 13.8725 mL | 34.6813 mL | |
| Ethanol | 10 mM | 0.6936 mL | 3.4681 mL | 6.9363 mL | 17.3406 mL |
| 15 mM | 0.4624 mL | 2.3121 mL | 4.6242 mL | 11.5604 mL | |
| 20 mM | 0.3468 mL | 1.7341 mL | 3.4681 mL | 8.6703 mL | |
| 25 mM | 0.2775 mL | 1.3873 mL | 2.7745 mL | 6.9363 mL | |
| 30 mM | 0.2312 mL | 1.1560 mL | 2.3121 mL | 5.7802 mL | |
| 40 mM | 0.1734 mL | 0.8670 mL | 1.7341 mL | 4.3352 mL | |
| 50 mM | 0.1387 mL | 0.6936 mL | 1.3873 mL | 3.4681 mL | |
| 60 mM | 0.1156 mL | 0.5780 mL | 1.1560 mL | 2.8901 mL | |
| 80 mM | 0.0867 mL | 0.4335 mL | 0.8670 mL | 2.1676 mL | |
| 100 mM | 0.0694 mL | 0.3468 mL | 0.6936 mL | 1.7341 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
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