Copy Link Print Information

Elesclomol

(Synonyms: STA-4783)
130 Cited Publications
Revisión del cliente

Based on 130 publication(s) in Google Scholar

Elesclomol (STA-4783) is a potent copper ionophore and promotes copper-dependent cell death (cuproptosis). Elesclomol specifically binds ferredoxin 1 (FDX1) α2/α3 helices and β5 strand. Elesclomol inhibits FDX1-mediated Fe-S cluster biosynthesis. Elesclomol is an oxidative stress inducer that induces cancer cell apoptosis. Elesclomol is a reactive oxygen species (ROS) inducer. Elesclomol can be used for Menkes and associated disorders of hereditary copper deficiency research.

Para uso exclusivo en investigación. No vendemos a pacientes.

  • Pureza: 99.19%
  • No. CAS: 488832-69-5
  • Fòrmula: C19H20N4O2S2
  • Peso molecular:400.52
  • Almacenamiento:
    Powder   -20°C, 3 years , 4°C, 2 years ; In solvent   -80°C, 1 year , -20°C, 6 months
  • Elesclomol Chemical Structure
    Elesclomol Chemical Structure
  • Experimental Validation Results for Elesclomol
  • Experimental Validation Results for Elesclomol
  • Experimental Validation Results for Elesclomol
  • Experimental Validation Results for Elesclomol
No. CAS: 488832-69-5
Tamaño
Precio
Stock
Cantidad
Amount: USD 0.00
Please select quantity
or
or

* Seleccione Cantidad antes de agregar artículos.

To place orders, for customer services and technical support, please contact: MedChemExpress USA

Tel: 609-228-6898 E-mail: [email protected] [email protected]

Data Download
Other Forms of Elesclomol:

To place orders, for customer services and technical support, please contact:

609-228-6898
[email protected] [email protected]
Encuentre su distribuidor local Your local distributor: Hycultec GmbHHycultec
  • Actividad biológica
  • Chemical Information
  • Solvente y solubilidad
  • Pureza y Documentación
  • Referencias
  • Help & FAQs
You May Still Need
Top Publications Citing

Use of MCE Products

Publications Citing Use of MedChemExpress (MCE) Elesclomol

More
Customer Validation & Images
IFCell Proliferation/Viability Assay
  • Cell Proliferation/Viability Assay
  • Cell Proliferation/Viability Assay
  • Cell Proliferation/Viability Assay
  • IF
Keywords
MOQ
Minimum order quantity
100 mg

Obtener un presupuesto En stock

Other size
Obtener un presupuesto
Please select quantity
Amount: USD 0.00
Sign in to MedChemExpress Inicie sesiòn
Registrar
Sign in to MedChemExpress
Registrar una cuenta nueva

At least 6 characters

Personalize your experience, you are currently not signed in. For a better experience, please create an online profile, you can:

Obtain points redemption prizes
Check out faster
Add multiple shipping locations
View orders
Assay Types
  • Elesclomol Chemical Structure
    Elesclomol Chemical Structure
    1/16
  • 1/16

    Elesclomol purchased from MedChemExpress. Usage Cited in: J Hazard Mater. 2024 Jul 31:477:135391. [Abstract]

    Customer Validation
     Elesclomol (20-80 nM; 6-24 h) with copper (ES/Cu) promotes cell death in a dose-dependent manner and cell growth in GCs.
    (b) Cell viability of ovarian granulosa cells under concentration gradients of 3-NP, Cu and ES, with a dashed line indicating the inhibition rate of 50% (IC50); (e) The survival ratio of mGCs treated with 40nM ES or 10μM TTM and exposed to a copper concentration gradient was assessed by CCK-8 assay.

  • 1/16

    Elesclomol purchased from MedChemExpress. Usage Cited in: Nat Chem Biol. 2019 Jul;15(7):681-689. [Abstract]

    Customer Validation
     The viability of 724 barcoded cell lines was determined for 8 concentrations of elesclomol and the calculated area under the curve (AUC) is presented as box plot for different lineages.
    Elesclomol is very potent in inducing cell death across all lineages with most cells showing sensitivity at doses above 100nM.

  • 1/16

    Elesclomol purchased from MedChemExpress. Usage Cited in: Nat Chem Biol. 2019 Jul;15(7):681-689. [Abstract]

    Customer Validation
     The viability of T47D cells cultured in the presence of galactose (Hi-Mito state) was examined following the addition of either elesclomol in the presence or absence of the copper chelator tetrathiomolybdate (TTM) at 10uM concentration.

  • 1/16

    Elesclomol purchased from MedChemExpress. Usage Cited in: Biomolecules. 2019 Jul 24;9(8):298. [Abstract]

    Customer Validation
     Confocal images of MitoSOX fluorescence intensity in CV-1 cells at the 20-min time point after E:C (elesclomol:copper)- treatment in the presence and absence of the mitochondrial superoxide scavenger MitoTEMPO.

  • Elesclomol