AMPA receptor modulator-4
AMPA receptor modulator-4, a 3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-dioxide (BTD), is an orally active positive allosteric modulator of the AMPA receptors (AMPAR PAMs). AMPA receptor modulator-4 can cross the blood-brain barrier. AMPA receptor modulator-4 increases the cognition performance and improves working memory performance in mice.
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- No. CAS: 2917551-59-6
- Fòrmula: C11H12ClFN2O2S
- Peso molecular:290.74
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Almacenamiento:
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Actividad biológica
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Chemical Information
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Actividad biológica
AMPA receptor modulator-4 (compound 15e) has pEC50 of 5.66 on the calcium influx induced by 1 mM Glutamate on HEK293 cells stably expressing the GluA2(Q) subunit[1].
AMPA receptor modulator-4 has EC2x=2.1 μM (FlipR)-1.5 μM (FDSS) [1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
AMPA receptor modulator-4 (1 and 3 mg/kg; po) 1 h before the three sessions significantly increases the cognition performance of CD1 mice[1].
AMPA receptor modulator-4 (0.03, 0.1 and 0.3 mg/kg; ip) improves the performance of spontaneous alternation and improves working memory performance in C57BI/6 mice[1].
AMPA receptor modulator-4 (30, 100 mg/kg; po; once) has non-pro-convulsant effect in NMRI mice[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Anesthetized rats[1]
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Dosage:10 and 30 mg/kg
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Administration:IP; once
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Result:Increased the duration of the the Long-Term Potentiation (LTP) at a dose of 10 mg/kg.
Chemical Information
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No. CAS 2917551-59-6
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Peso molecular 290.74
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Fòrmula C11H12ClFN2O2S
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SMILES
O=S1(C2=CC(Cl)=CC=C2N(C3CC3)CN1CF)=O
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
[1]. Eric Goffin, et al. New insights in the development of positive allosteric modulators of α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors belonging to 3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-dioxides: Introduction of (mono/difluoro)methyl groups at the 2-position of the thiadiazine ring. Eur J Med Chem. 2023 Mar 15;250:115221. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
AMPA receptor modulator-4 Related Classifications
HY-149975 Related Classifications
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