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Referencia número: HY-114641

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BIIL-260

1 Cited Publications

Revisión del cliente

Based on 1 publication(s) in Google Scholar

BIIL-260 is a potent and long-acting orally active leukotriene B(4) receptor LTB₄ antagonist, with anti-inflammatory activity. BIIL-260 interacts with the LTB₄ receptor in a saturable, reversible, and competitive manner, has high affinity to the LTB₄ receptor on isolated human neutrophil cell membranes with the K_i value of 1.7 nM.

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No. CAS: 204974-93-6
Fòrmula: C₃₀H₃₀N₂O₃
Peso molecular:466.57

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Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (264 KB)

BIIL-260 Chemical Structure

No. CAS: 204974-93-6

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

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Bioz

Actividad biológica

Descripciòn

IC₅₀ & Target

Ki: 1.7 nM (LTB₄ receptor)^[1]

Ver todos los productos específicos de isoformas Leukotriene Receptor :

In Vitro

BIIL-260 potently inhibits LTB₄-induced intracellular Ca²⁺ release in human neutrophils with the IC₅₀ value of 0.82 nM.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

No. CAS 204974-93-6
Peso molecular 466.57
Fòrmula C₃₀H₃₀N₂O₃
SMILES

N=C(N)C1=CC=C(C=C1)OCC2=CC=CC(COC3=CC=C(C=C3)C(C4=CC=C(C=C4)O)(C)C)=C2
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Room temperature in continental US; may vary elsewhere.
Almacenamiento

Please store the product under the recommended conditions in the Certificate of Analysis.

Publications (1)

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J Leukoc Biol

Caging giants: Characterizing the molecular mechanisms of neutrophil swarming against Candida albicans hyphae. [Abstract]

2025 Jun 6:qiaf082. PMID: 40476443

Pureza y Documentación

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Pureza: 99.98%

Assay: 99.98%

ee.: 99.98%

Ficha de datos (264 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instrucciones de manejo (2659 KB)

Referencias

[1]. Birke FW, et al. In vitro and in vivo pharmacological characterization of BIIL 284, a novel and potent leukotriene B(4) receptor antagonist. J Pharmacol Exp Ther. 2001 Apr;297(1):458-66. [Content Brief]

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How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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BIIL-260

1 Cited Publications

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BIIL-260

Publications Citing Use of MedChemExpress (MCE) BIIL-260

Ver todos los productos específicos de isoformas Leukotriene Receptor

Actividad biológica

Chemical Information

Publications (1)

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BIIL-260 Related Classifications

HY-114641 Related Classifications