BJH-86
BJH-86 is a soluble mitochondrial complex 1 inhibitor (oxygen consumption rate inhibition IC50 = 5 μM). BJH-86 exhibits weak inhibitory activity against phosphodiesterase 10A (PDE10A) (IC50 >10 μM). BJH-86 can reduce cellular oxygen consumption and inhibit cancer cell proliferation. BJH-86 can be used for the research of cancer, such as lung cancer.
Para uso exclusivo en investigación. No vendemos a pacientes.
- No. CAS: 3067849-10-6
- Fòrmula: C23H21N3O2
- Peso molecular:371.43
-
Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Actividad biológica
-
Chemical Information
- Pureza y Documentación
- Referencias
-
Help & FAQs
Actividad biológica
|
PDE10A |
BJH-86 (1-10 μM, 30 min-96 h) potently inhibits mitochondrial complex I (oxygen consumption rate inhibition IC50 = 5 μM) in A549 human lung cancer cells and EO771 murine breast cancer cells[1].
BJH-86 exhibits weak inhibitory activity against phosphodiesterase 10A (PDE10A, IC50 >10 μM) [1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Animal Model:C57Bl6 mice bearing EO771 xenografts[1]
-
Dosage:2 mg/kg single dose 1 h before radiotherapy and 30 mg/kg repeated administration
-
Administration:Intravenously injection
-
Result:Reduced tumor hypoxia.
Enhanced radiosensitivity (5 Gy) .
Prolonged tumor growth delay from 2 days to 4 days.
Chemical Information
-
No. CAS 3067849-10-6
-
Peso molecular 371.43
-
Fòrmula C23H21N3O2
-
SMILES
COC1=CC=C2N=CC=C(CC3=CC=CC(C4=CN(C5COC5)N=C4)=C3)C2=C1
-
Envío
Room temperature in continental US; may vary elsewhere.
-
Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
BJH-86 Related Classifications
HY-178987 Related Classifications
Powered by Bioz