D-Cysteine
Based on 1 Customer Validation
D-Cysteine, the D-isomer of cysteine, is an orally active antibacterial agent and a regulator of neural progenitor cell proliferation. D-Cysteine can inhibit Escherichia coli, Streptococcus mutans, and Streptococcus sanguinis. The no-observed-adverse-effect level of D-Cysteine in rats should be less than 500 mg/kg/day.
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- Pureza: 98.0%
- No. CAS: 921-01-7
- Fòrmula: C3H7NO2S
- Peso molecular:121.16
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Almacenamiento:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Actividad biológica
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Chemical Information
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Actividad biológica
D-Cysteine (0-60 mM; 24 h) inhibits the growth and cariogenic virulence of dual-species biofilms formed by S. mutans and S. sanguinis[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Male Crl:CD(SD)IGS rats[2]
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Dosage:500, 1,000 and 2,000 mg/kg
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Administration:Oral gavage (i.g.); 28 days
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Result:Caused anemia and renal injuries such as basophilic tubules with eosinophilic material in the lumen, increased numbers of basophilic tubules, and crystal deposition in the medulla in the 2,000 mg/kg/day-treated group.
Caused sperm granuloma in the epididymis, necropsy findings suggestive of focal erosion in the stomach mucosa, and salivation in the 1,000 or 2,000 mg/kg/day-treated groups. One rat in the 2,000 mg/kg/day-treated group died due to renal failure.
Chemical Information
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No. CAS 921-01-7
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Appearance Solid
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Peso molecular 121.16
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Fòrmula C3H7NO2S
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Color White to off-white
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SMILES
N[C@H](CS)C(O)=O
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Structure Classification
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Initial Source
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvente y solubilidad
H2O : 4 mg/mL (33.01 mM; ultrasonic and warming and heat to 60°C)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Pureza y Documentación
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Ficha de datos (272 KB)
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SDS (392 KB)
- English - EN (392 KB)
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Instrucciones de manejo (2659 KB)
Referencias
[1]. Guo X1, et al. Effect of D-cysteine on dual-species biofilms of Streptococcus mutans and Streptococcus sanguinis. Sci Rep. 2019 Apr 30;9(1):6689. [Content Brief]
[2]. Shibui Y, et al. Comparisons of l-cysteine and d-cysteine toxicity in 4-week repeated-dose toxicity studies of rats receiving daily oral administration. J Toxicol Pathol. 2017 Jul;30(3):217-229. [Content Brief]
[3]. Soutourina J, et al. Role of D-cysteine desulfhydrase in the adaptation of Escherichia coli to D-cysteine. J Biol Chem. 2001 Nov 2;276(44):40864-72. [Content Brief]
[4]. Roychaudhuri R, et al. Mammalian D-cysteine: A novel regulator of neural progenitor cell proliferation Mammalian D-cysteine: A novel regulator of neural progenitor cell proliferation Endogenous D-cysteine, the stereoisomer with rapid spontaneous in vitro racemization rate, has major neural roles. Bioessays. 2022 Jul;44(7):e2200002. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O | 1 mM | 8.2535 mL | 41.2677 mL | 82.5355 mL | 206.3387 mL |
| 5 mM | 1.6507 mL | 8.2535 mL | 16.5071 mL | 41.2677 mL | |
| 10 mM | 0.8254 mL | 4.1268 mL | 8.2535 mL | 20.6339 mL | |
| 15 mM | 0.5502 mL | 2.7512 mL | 5.5024 mL | 13.7559 mL | |
| 20 mM | 0.4127 mL | 2.0634 mL | 4.1268 mL | 10.3169 mL | |
| 25 mM | 0.3301 mL | 1.6507 mL | 3.3014 mL | 8.2535 mL | |
| 30 mM | 0.2751 mL | 1.3756 mL | 2.7512 mL | 6.8780 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
D-Cysteine Related Classifications
HY-W018555 Related Classifications
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