Dynorphin A (1-8)
Based on 1 Customer Validation
Dynorphin A (1-8) is a ligand with preference for the κ-opioid receptor, and its IC50 value against human placental κ-opioid receptor is 330 nM. Dynorphin A (1-8) mediates neuroprotective effects by inhibiting oxidative stress, suppressing apoptosis, and competitively displacing the binding of κ partial agonists. Dynorphin A (1-8) is the dominant opioid peptide in human placental villi and tissue extracts; it undergoes rapid hydrolysis and can enter the central nervous system via intranasal administration. Dynorphin A (1-8) can be used in studies related to ischemic stroke.
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- Pureza: 99.69%
- No. CAS: 75790-53-3
- Fòrmula: C46H72N14O10
- Peso molecular:981.15
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Almacenamiento:
Stored under nitrogen, away from moisture.
Powder -80°C, 2 years , -20°C, 1 year* In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
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Actividad biológica
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Chemical Information
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Solvente y solubilidad
- Pureza y Documentación
- Referencias
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Help & FAQs
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Actividad biológica
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κ Opioid Receptor/KOR |
Human Endogenous Metabolite |
Dynorphin A (1-8) inhibits 3H-EKC binding to the purified 63 kDa kappa opioid receptor from human placental villus tissue with an IC50 of 330 nM[2].
Dynorphin A (1-8) inhibits 3H-Bremazocine binding to the purified 63 kDa kappa opioid receptor from human placental villus tissue with an IC50 of 610 nM and a Ki of 303 nM[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Sprague-Dawley (SD) (male, 240-270 g, middle cerebral artery occlusion modeling)[1]
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Dosage:100 nmol (intranasal, neuroprotective); 100 nmol (intravenous, no effect)
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Administration:intranasal; single dose at start of surgery; intravenous; single dose at start of surgery
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Result:Significantly reduced neurological deficit scores.
Significantly reduced cerebral infarction volume.
Significantly reduced brain water content.
Increased neuron number, improved cell arrangement, and reduced neuronal degeneration, necrosis, and pyknosis.
Significantly reduced the number of TUNEL-positive apoptotic neurons.
Significantly increased Bcl-2 expression and decreased Bax and Caspase-3 expression in the ischemic cortex.
Significantly increased serum SOD activity and decreased serum MDA concentration.
Showed no statistically significant effects on neurological deficit scores, cerebral infarction volume, brain water content, TUNEL-positive neuron count, or apoptosis-related protein expression compared to the MCAO model group.
Chemical Information
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No. CAS 75790-53-3
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Appearance Solid
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Peso molecular 981.15
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Fòrmula C46H72N14O10
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Color White to off-white
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Sequence
Tyr-Gly-Gly-Phe-Leu-Arg-Arg-Ile
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Sequence Shortening
YGGFLRRI
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Structure Classification
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Initial Source
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Stored under nitrogen, away from moisture
Powder -80°C 2 years -20°C 1 year * In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen, away from moisture)
Solvente y solubilidad
H2O : 100 mg/mL (101.92 mM; Need ultrasonic)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Pureza y Documentación
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Ficha de datos (274 KB)
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SDS (254 KB)
- English - EN (254 KB)
- Français - FR (254 KB)
- Deutsch - DE (254 KB)
- Norwegian - NO (254 KB)
- Español - ES (254 KB)
- Swedish - SV (254 KB)
- Italian - IT (254 KB)
- Korean - KR (254 KB)
- Portuguese - PT (254 KB)
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Instrucciones de manejo (2659 KB)
Referencias
[1]. Chen M, et al. Dynorphin A (1-8) inhibits oxidative stress and apoptosis in MCAO rats, affording neuroprotection through NMDA receptor and κ-opioid receptor channels. Neuropeptides. 2021;89:102182. [Content Brief]
[2]. Ahmed MS, et al. Opioid binding properties of the purified kappa receptor from human placenta. Life Sci. 1989;44(13):861-871. [Content Brief]
[3]. Agbas A, et al. Dynorphin A(1-8) in human placenta: amino acid sequence determined by tandem mass spectrometry. Peptides. 1995;16(4):623-627. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O | 1 mM | 1.0192 mL | 5.0961 mL | 10.1921 mL | 25.4803 mL |
| 5 mM | 0.2038 mL | 1.0192 mL | 2.0384 mL | 5.0961 mL | |
| 10 mM | 0.1019 mL | 0.5096 mL | 1.0192 mL | 2.5480 mL | |
| 15 mM | 0.0679 mL | 0.3397 mL | 0.6795 mL | 1.6987 mL | |
| 20 mM | 0.0510 mL | 0.2548 mL | 0.5096 mL | 1.2740 mL | |
| 25 mM | 0.0408 mL | 0.2038 mL | 0.4077 mL | 1.0192 mL | |
| 30 mM | 0.0340 mL | 0.1699 mL | 0.3397 mL | 0.8493 mL | |
| 40 mM | 0.0255 mL | 0.1274 mL | 0.2548 mL | 0.6370 mL | |
| 50 mM | 0.0204 mL | 0.1019 mL | 0.2038 mL | 0.5096 mL | |
| 60 mM | 0.0170 mL | 0.0849 mL | 0.1699 mL | 0.4247 mL | |
| 80 mM | 0.0127 mL | 0.0637 mL | 0.1274 mL | 0.3185 mL | |
| 100 mM | 0.0102 mL | 0.0510 mL | 0.1019 mL | 0.2548 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Dynorphin A (1-8) Related Classifications
HY-P2159 Related Classifications
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