FGF22-IN-1
Based on 2 publication(s) in Google Scholar
FGF22-IN-1 (compound c1) is a potent CD4 D1 inhibitor. FGF22-IN-1 can be used as immunosuppressive agent.
Para uso exclusivo en investigación. No vendemos a pacientes.
- Pureza: 98.07%
- No. CAS: 113143-13-8
- Fòrmula: C14H11N3OS
- Peso molecular:269.32
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Almacenamiento:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Actividad biológica
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Chemical Information
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Solvente y solubilidad
- Pureza y Documentación
- Referencias
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) FGF22-IN-1
More
Actividad biológica
CD4 D1[1]
Chemical Information
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No. CAS 113143-13-8
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Appearance Solid
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Peso molecular 269.32
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Fòrmula C14H11N3OS
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Color White to light yellow
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SMILES
O=C(C1=CC=CS1)N/N=C/C2=CNC3=C2C=CC=C3
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Publications (2)
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Journal Impact Factor
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Most Recent
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Int Immunopharmacol
2024 Jan 25:127:111411. PMID: 38113689 -
Neuropharmacology
Enhanced interleukin-16-CD4 signaling in CD3 T cell mediates neuropathic pain via activating astrocytes in female mice. [Abstract]2024 Nov 15:259:110115. PMID: 39137872
Solvente y solubilidad
DMSO : 100 mg/mL (371.31 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.5 mg/mL (9.28 mM); Clear solution
This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL.
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Pureza y Documentación
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Ficha de datos (275 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Instrucciones de manejo (2659 KB)
Referencias
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 3.7131 mL | 18.5653 mL | 37.1306 mL | 92.8264 mL |
| 5 mM | 0.7426 mL | 3.7131 mL | 7.4261 mL | 18.5653 mL | |
| 10 mM | 0.3713 mL | 1.8565 mL | 3.7131 mL | 9.2826 mL | |
| 15 mM | 0.2475 mL | 1.2377 mL | 2.4754 mL | 6.1884 mL | |
| 20 mM | 0.1857 mL | 0.9283 mL | 1.8565 mL | 4.6413 mL | |
| 25 mM | 0.1485 mL | 0.7426 mL | 1.4852 mL | 3.7131 mL | |
| 30 mM | 0.1238 mL | 0.6188 mL | 1.2377 mL | 3.0942 mL | |
| 40 mM | 0.0928 mL | 0.4641 mL | 0.9283 mL | 2.3207 mL | |
| 50 mM | 0.0743 mL | 0.3713 mL | 0.7426 mL | 1.8565 mL | |
| 60 mM | 0.0619 mL | 0.3094 mL | 0.6188 mL | 1.5471 mL | |
| 80 mM | 0.0464 mL | 0.2321 mL | 0.4641 mL | 1.1603 mL | |
| 100 mM | 0.0371 mL | 0.1857 mL | 0.3713 mL | 0.9283 mL |
FGF22-IN-1 Related Classifications
HY-148432 Related Classifications
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