CISD1 - CDGSH iron sulfur domain 1 Gene

Also Known as ZCD1; MDS029; C10orf70; mitoNEET

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 55847

About CISD1

Cytogenetic location: 10q21.1 Genomic coordinates (GRCh38): 10:58,269,162-58,289,586 (from NCBI)

This gene has 4 transcripts (splice variants), 227 orthologues and 2 paralogues. Ubiquitous expression in heart (RPKM 13.4), small intestine (RPKM 9.9) and 23 other tissues.

Summary

This gene encodes a protein with a CDGSH iron-sulfur domain and has been shown to bind a redox-active [2Fe-2S] cluster. The encoded protein has been localized to the outer membrane of mitochondria and is thought to play a role in regulation of oxidation. Genes encoding similar proteins are located on chromosomes 4 and 17, and a pseudogene of this gene is located on chromosome 2. [provided by RefSeq, Feb 2012]

CISD1 Products (1)

mRNA	Protein	Name
NM_018464.5	NP_060934.1	CDGSH iron-sulfur domain-containing protein 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Referencias	Source
enables 2 iron, 2 sulfur cluster binding	IDA IDA: Inferred from direct assay	17766439	GOA
enables L-cysteine transaminase activity	IDA IDA: Inferred from direct assay	36194135	GOA
enables identical protein binding	IPI IPI: Inferred from physical interaction	17766439	GOA
enables protein homodimerization activity	IDA IDA: Inferred from direct assay	17905743	GOA
enables pyridoxal phosphate binding	IDA IDA: Inferred from direct assay	36194135	GOA

Biological Process GO Annotation	Evidence	Referencias	Source
involved in protein maturation by [2Fe-2S] cluster transfer	IDA IDA: Inferred from direct assay	21788481	GOA

Cellular Component GO Annotation	Evidence	Referencias	Source
located in mitochondrion	IDA IDA: Inferred from direct assay	17376863	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CISD1 Protein Structure

MitoNEET_N

zf-CDGSH

0
100
108 a.a.

Protein Preferred Names	Protein Names
CDGSH iron-sulfur domain-containing protein 1	zinc finger CDGSH-type domain 1

CISD1 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Referencias
Intra	CISD1	Q9NZ45	CISD2	Homo sapiens	Q8N5K1	Anti Tag CoIP	33961781
Intra	CISD1	Q9NZ45	CISD1	Homo sapiens	Q9NZ45	X-Ray Diffraction	17766440
Intra	CISD1	Q9NZ45	WDR45	Homo sapiens	Q9Y484	Anti Tag CoIP	33961781
Intra	CISD1	Q9NZ45	PDLIM7	Homo sapiens	Q9NR12	Anti Tag CoIP	33961781
Intra	CISD1	Q9NZ45	CISD1	Homo sapiens	Q9NZ45	Ion Exchange Chrom	17766440
Intra	CISD1	Q9NZ45	CISD1	Homo sapiens	Q9NZ45	X-Ray Diffraction	17766439
Intra	CISD1	Q9NZ45	CHCHD2	Homo sapiens	Q9Y6H1	Anti Tag CoIP	33961781
Intra	CISD1	Q9NZ45	CISD1	Homo sapiens	Q9NZ45	GMS	17766439
Intra	CISD1	Q9NZ45	NR4A2	Homo sapiens	P43354	Display Tech	20195357

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant CISD1 Proteins

Referencia número	Nombre del producto	Accession	Pureza
HY-P76262	CISD1 Protein, Human (His)	Q9NZ45/NP_060934.1 (K32-T108)	≥ 95%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases	Alias
Wolfram Syndrome	Didmoad Syndrome Didmoad Diabetes Insipidus And Mellitus With Optic Atrophy And Deafness Wfs Diabetes Insipidus, Diabetes Mellitus, Optic Atrophy, And Deafness Didmoadud Diabetes Insipidus-Diabetes Mellitus-Optic Atrophy-Deafness Syndrome Diabetes Insipidus-Diabetes Mellitus-Optic Atrophy-Hearing Loss Syndrome
Wolfram Syndrome 2	WFS2
Fanconi Anemia, Complementation Group D2	Fanconi Anemia Complementation Group D2 FANCD2 Fad2 Fa4 Fancd Fanconi Pancytopenia Type 4 Fanconi Anemia, Complementation Group D Fanconi Pancytopenia, Type 4 Facd Fanconi Anemia Complementation Group D

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (6)

Referencia número	Nombre del producto	Efecto	Pureza	Rare Diseases
HY-135231	NL-1		99.45%	Unkown
HY-114520	TT01001	Inhibitor	99.93%	Unkown
HY-106159	SB-T-101141	Inducer	/	Unkown
HY-RS02723	CISD1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS17379	Cisd1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS23833	Cisd1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	CISD1	VGNC	VGNC:27371
Rattus norvegicus	CISD1	RGD	RGD:1309529
Mus musculus	CISD1	MGD	MGI:1261855
Others	CISD1	NCBI