NOS-IN-4
NOS-IN-4 (Compound 3) is a neuronal nitric oxide synthase (nNOS) inhibitor with an IC50 of 4.00 μM that inhibits nNOS activity. The combined use of alpha-lipoic acid and NOS-IN-4 has a protective effect against MPTP (HY-W114750)-induced dopamine depletion in the mouse brain. NOS-IN-4 can be used for the research of neurological disease.
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- No. CAS: 3737-39-1
- Fòrmula: C11H10N2S
- Peso molecular:202.28
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Actividad biológica
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Chemical Information
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Actividad biológica
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nNOS 4.00 μM (IC50) |
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| Caco-2 | Inhibition |
-6.99 %
Compound: LTA
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Antiviral activity determined as inhibition of SARS-CoV-2 induced cytotoxicity of Caco-2 cells at 10 uM after 48 hours by high content imaging
Antiviral activity determined as inhibition of SARS-CoV-2 induced cytotoxicity of Caco-2 cells at 10 uM after 48 hours by high content imaging
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10.21203/rs.3.rs-23951/v1 |
NOS-IN-4 (up to 100 µM) is inactive in protecting mouse hippocampal neuronal HT22 cells from glutamate-induced cytotoxicity[1].
NOS-IN-4 (up to 100 µM) is inactive in preventing glutamate-induced glutathione depletion in mouse hippocampal neuronal HT22 cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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No. CAS 3737-39-1
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Peso molecular 202.28
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Fòrmula C11H10N2S
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SMILES
N=C(NC=1C=CC=CC1)C=2SC=CC2
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
NOS-IN-4 Related Classifications
HY-W839206 Related Classifications
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