Novel lipoic acid analogues that inhibit nitric oxide synthase

  • Bioorg Med Chem Lett. 2002 Jun 3;12(11):1439-42. doi: 10.1016/s0960-894x(02)00216-0.
Jeremiah J Harnett  1 ,  Michel Auguet ,  Isabelle Viossat ,  Christine Dolo ,  Dennis Bigg ,  Pierre-E Chabrier
Affiliations
  • 1. Department of Medicinal Chemistry, Beaufour-Ipsen Research Laboratories, Institute Henri Beaufour, 5, Avenue du Canada, 91966 Cedex, Les Ulis, France. [email protected]
PMID: 12031315 DOI: 10.1016/s0960-894x(02)00216-0
Abstract

The synthesis and biological activity of novel lipoic acid analogues are reported. Lipoic acid and structural homologues coupled to arylthiophene amidine via carboxamide linkers are metabolic Antioxidants capable of protecting neuronal cells against glutamate cytotoxicity, preventing loss of intracellular glutathione, and inhibit nitric oxide synthase.

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