Pinocembrin chalcone
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Pinocembrin chalcone (2',4',6'-Trihydroxychalcone) is an antibacterial compound from Helichrysum Trilineatum. Pinocembrin chalcone facilitates AMP-activated protein kinase (AMPK) activation, improves glucose tolerance, increases muscle FAO and reduces fat accumulation in the liver and skeletal muscles in high-fat diet-induced (HFD) diabetic mice. Pinocembrin chalcone is promising for research of gastric ulcers and diabetes.
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- Pureza: 98.74%
- No. CAS: 4197-97-1
- Fòrmula: C15H12O4
- Peso molecular:256.25
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Almacenamiento:
4°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
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Actividad biológica
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Chemical Information
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Actividad biológica
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HEK293 | IC50 |
25.4 μM
Compound: 8c
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Inhibition of human SGLT1 expressed in HEK293 cells assessed as reduction in 2-deoxyglucose uptake pretreated for 10 mins followed by 2-deoxyglucose addition in presence of sodium buffer measured after 1 hr by resazurin dye based fluorescence assay
Inhibition of human SGLT1 expressed in HEK293 cells assessed as reduction in 2-deoxyglucose uptake pretreated for 10 mins followed by 2-deoxyglucose addition in presence of sodium buffer measured after 1 hr by resazurin dye based fluorescence assay
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[PMID: 28098449] |
| HEK293 | IC50 |
33.3 μM
Compound: 8c
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Inhibition of human SGLT2 expressed in HEK293 cells assessed as reduction in 2-deoxyglucose uptake pretreated for 10 mins followed by 2-deoxyglucose addition in presence of sodium buffer measured after 1 hr by resazurin dye based fluorescence assay
Inhibition of human SGLT2 expressed in HEK293 cells assessed as reduction in 2-deoxyglucose uptake pretreated for 10 mins followed by 2-deoxyglucose addition in presence of sodium buffer measured after 1 hr by resazurin dye based fluorescence assay
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[PMID: 28098449] |
| RBL-1 | IC50 |
140 μM
Compound: 3
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Inhibition of 5-lipoxygenase in rat RBL1 cells
Inhibition of 5-lipoxygenase in rat RBL1 cells
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10.1007/s00044-013-0745-7 |
| RBL-1 | IC50 |
140 μM
Compound: 3
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Inhibition of cyclooxygenase in rat RBL1 cells
Inhibition of cyclooxygenase in rat RBL1 cells
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10.1007/s00044-013-0745-7 |
| RBL-1 | IC50 |
140 μM
Compound: 4
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In vitro inhibition against 5-lipoxygenase in RBL-1 cells was determined
In vitro inhibition against 5-lipoxygenase in RBL-1 cells was determined
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[PMID: 8254620] |
Pinocembrin chalcone (1.0 μg) is active at inhibiting the growth of S. aureus.[1].
Pinocembrin chalcone (10 μM, 24 h) markedly increases fatty acid oxidation rate and increases the phosphorylation of AMPKα with no cytotoxicity in C2C12 myotubes[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:C2C12 myotubes
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Concentration:10 μM
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Incubation Time:24 h
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Result:Stimulated AMPK phosphorylation at much lower concentrations (1 μM) within 2 h in C2C12 myotubes.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:HFD-induced diabetic mice[2]
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Dosage:30 mg/kg
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Administration:oral gavage, daily for 3 weeks
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Result:Reduced the circulating FFA levels and fat accumulation in the liver and muscles by increasing FAO, which improved glucose tolerance in HFD-induced diabetic mice.
Chemical Information
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No. CAS 4197-97-1
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Appearance Solid
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Peso molecular 256.25
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Fòrmula C15H12O4
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Color Light yellow to yellow
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SMILES
O=C(C1=C(O)C=C(O)C=C1O)/C=C/C2=CC=CC=C2
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Synonyms
2',4',6'-Trihydroxychalcone
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Structure Classification
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Initial Source
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
4°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
Pureza y Documentación
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Ficha de datos (271 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Instrucciones de manejo (2659 KB)
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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