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Referencia número: HY-181026

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RP-4029

RP-4029 is a selective, covalent hPolθ inhibitor (IC₅₀s: 0.013 nM for hPolθ; 6.6 nM for mPolθ). RP-4029 can be used in the research of homologous recombination (HR)-deficient cancers.

Para uso exclusivo en investigación. No vendemos a pacientes.

Fòrmula: C₂₉H₂₃F₆N₃O₄S
Peso molecular:623.57

Almacenamiento:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (268 KB)

RP-4029 Chemical Structure

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Actividad biológica
- Descripciòn
- IC₅₀ & Target
Chemical Information
Pureza y Documentación
Referencias
Calculators
Help & FAQs
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Bioz

Actividad biológica

Descripciòn

RP-4029 is a selective, covalent hPolθ inhibitor (IC₅₀s: 0.013 nM for hPolθ; 6.6 nM for mPolθ). RP-4029 can be used in the research of homologous recombination (HR)-deficient cancers^[1].

IC₅₀ & Target

IC₅₀s: 0.013 nM for hPolθ; 6.6 nM for mPolθ^[1]

Ver todos los productos específicos de isoformas DNA/RNA Synthesis :

Chemical Information

Peso molecular 623.57
Fòrmula C₂₉H₂₃F₆N₃O₄S
SMILES

O=C(N(C1=CC=CC=C1)CC#CCNC(C2=C(NS(C=C)(=O)=O)C=CC=C2)=O)CC3=CC=C(C(F)(F)F)C=C3C(F)(F)F
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureza y Documentación

Select Batch:

Pureza: 99.98%

Assay: 99.98%

ee.: 99.98%

Ficha de datos (268 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instrucciones de manejo (2659 KB)

Referencias

[1]. Bubenik M, et al. Design of a Targeted Covalent Probe to Interrogate the DNA Polymerase Activity of Polθ[J]. ACS Medicinal Chemistry Letters, 2026.

Calculators

Calculadora de molaridad

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Calculadora de dilución

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Actividad biológica
- Descripciòn
- IC₅₀ & Target
Chemical Information
Pureza y Documentación
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RP-4029

Ver todos los productos específicos de isoformas DNA/RNA Synthesis

Actividad biológica

Chemical Information

Pureza y Documentación

Referencias

Calculators

Help & FAQs

RP-4029 Related Classifications

HY-181026 Related Classifications