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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
349 Results for "
Rb
" in MedChemExpress (MCE) Product Catalog:
Products (349)
349 Results for "Rb" in MCE Product Catalog:
16
16 Publications Verification
Referencia número: HY-N0039
No. CAS: 41753-43-9
Synonyms: Gypenoside III
11
11 Cited Publications
LDC4297 is a selective inhibitor of CDK7 with an IC50 value of 0.13 nM. LDC4297 inhibits human cytomegalovirus (HCMV) replication with an EC50 value of 24.5 nM. LDC4297 shows broad antiviral activities to Herpesviridae, Adenoviridae, Poxviridae, Retroviridae and Orthomyxoviridae with EC50 value of 0.02-1.21 μM. LDC4297 can be used for the research of infection .
11
11 Cited Publications
LDC4297 hydrochloride is a selective inhibitor of CDK7 with an IC50 value of 0.13 nM. LDC4297 hydrochloride inhibits human cytomegalovirus (HCMV) replication with an EC50 value of 24.5 nM. LDC4297 hydrochloride shows broad antiviral activities to Herpesviridae, Adenoviridae, Poxviridae, Retroviridae and Orthomyxoviridae with EC50 values of 0.02-1.21 μM. LDC4297 hydrochloride can be used for the research of infection .
5
5 Cited Publications
Referencia número: HY-N0904
No. CAS: 39262-14-1
Synonyms: Ginsenoside compound K; Ginsenoside K
Category:
Panax ginseng C. A. Meyer Triterpenes Terpenoids Plants Disease Research Fields Inflammation/Immunology Araliaceae
Target:
4
4 Cited Publications
Synonyms: ENT-50852; Rb-1515; WR-95704
Target:
Áreas de investigación:
Altretamine is an alkylating antineoplastic agent.
3
2
Target:
Áreas de investigación:
2
Cirtociclib (BLU-222) is an orally active and highly selective CDK2 inhibitor. Cirtociclib disrupts Rb signaling and causes G1 arrest and apoptosis in CCNE1-amplified endometrial cancer cells .
1
1 Cited Publications
Synonyms: QGC001; Rb150
Target:
Áreas de investigación:
Firibastat (QGC001), an orally active brain penetrating proagent of EC33, is a first-in-class brain aminopeptidase A (APA) inhibitor (Ki=200 nM). Firibastat selectively and specifically inhibits conversion of brain angiotensin-II into angiotensin-III and decreases blood pressure in hypertensive rats .
1
Category:
Panax ginseng C. A. Meyer Triterpenes Terpenoids Plants Disease Research Fields Inflammation/Immunology Araliaceae Cancer
Target:
1
1 Cited Publications
Referencia número: HY-P99142
Target:
Áreas de investigación:
1
1
1 Cited Publications
AD4 is an artemisinin derivative that is a proteolytic targeting chimera (PROTAC) targeting PCLAF. AD4 can effectively degrade PCLAF in RS4;11 cells (IC50: 0.6 nM), thereby activating the p21/Rb axis and exerting anti-tumor activity. AD4 also prolonged survival of RS4;11-transplanted NOD/SCID mice, with in vivo efficacy .
1
1 Cited Publications
Referencia número: HY-N7678
No. CAS: 110261-98-8
Category:
Panax ginseng C. A. Meyer Triterpenes Terpenoids Cucurbitaceae Plants Disease Research Fields Gynostemma pentaphyllum (Thunb.) Makino Araliaceae Cancer
Target:
1
1 Cited Publications
Synonyms: (1R,2R)-B13
Target:
Áreas de investigación:
D-NMAPPD ((1R,2R)-B13) is an acid ceramidase inhibitor. D-NMAPPD regulates NMDA receptor properties by enhancing endogenous production of ceramides. D-NMAPPD has anticancer effecs .
1
Target:
Áreas de investigación:
Etrasimod arginine is an orally available S1P receptor modulator that is a potent full agonist of the S1P1 receptor and has partial agonist activity at S1P4. Etrasimod arginine reduces inflammation in a CD4 +CD45RB high T cell-transferred mouse colitis model .
1
1 Cited Publications
Referencia número: HY-P74834
Pureza: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: IL12Rb2; IL-12R Subunit Beta-2; Interleukin 12 Receptor Subunit Beta 2; Interleukin-12 Receptor Beta-2 Chain; Interleukin-12 Receptor Subunit Beta-2; IL-12R-Beta-2; Interleukin 12 Receptor, Beta 2; IL-12Rb2; IL-12 Receptor Subunit Beta-2
1
1 Cited Publications
Referencia número: HY-P83231
Synonyms: MGC1490; Rab 11; Rab 11A; Rab-11; RAB11 A; RAB11; Rab11a; RAB11A member RAS oncogene family; Ras related protein Rab 11A; Ras related protein Rab11A; Ras-related protein Rab-11A; Rb11A; YL 8; YL8
1
1 Cited Publications
Referencia número: HY-P76370
Pureza: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: IL6ST; Interleukin Receptor Beta Chain; Interleukin 6 Cytokine Family Signal Transducer; Membrane Glycoprotein Gp130; Interleukin-6 Receptor Subunit Beta; IL6ST Nirs Variant 5; Membrane Glycoprotein 130; IL6ST Nirs Variant 2; IL-6Rb; IL6ST Nirs Variant 3
Target:
Áreas de investigación:
RB-3, a polycomb repressive complex 1 (PRC1) inhibitor, binds to RING1B-BMI1f, with a Kd of 2.8 μM .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
