Cirtociclib
Based on 2 publication(s) in Google Scholar
Cirtociclib (BLU-222) is an orally active and highly selective CDK2 inhibitor. Cirtociclib disrupts Rb signaling and causes G1 arrest and apoptosis in CCNE1-amplified endometrial cancer cells.
Para uso exclusivo en investigación. No vendemos a pacientes.
- Pureza: 98.63%
- No. CAS: 2888704-84-3
- Fòrmula: C15H17F2N7O2
- Peso molecular:365.34
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Almacenamiento:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Actividad biológica
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Chemical Information
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Solvente y solubilidad
- Pureza y Documentación
- Referencias
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Help & FAQs
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Apoptosis Compound Library
HY-L003
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Publications Citing Use of MedChemExpress (MCE) Cirtociclib
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Customer Validation & Images
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Cell Proliferation/Viability Assay
Actividad biológica
Cirtociclib (BLU-222) (25-250 nM; 0-288 h) exhibits antiproliferative activity against KLE and HEC-1-B cell lines[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
| NCT Number | Sponsor | Condition | Start Date |
Phase
|
|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Chemical Information
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No. CAS 2888704-84-3
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Appearance Solid
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Peso molecular 365.34
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Fòrmula C15H17F2N7O2
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Color White to light yellow
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SMILES
FC(OC1=CC(NC2=NC3=C(C=NN3CC4CCOCC4)N=C2)=NN1)F
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Synonyms
BLU-222
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Publications (2)
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Journal Impact Factor
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Most Recent
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Sci Signal
p16 expression confers sensitivity to CDK2 inhibitors in cyclin E1-driven ovarian cancers. [Abstract]2025 Nov 25;18(914):eadv0415. PMID: 41289358 -
Cirtociclib purchased from MedChemExpress. Usage Cited in: bioRxiv. 2026 Mar 18.
Cell viability after 4 days of treatment with Cirtociclib (BLU-222, 0.5-1 μM) and Tagtociclib at the indicated concentrations (average of three biological replicates each with three technical replicates).
Solvente y solubilidad
DMSO : 100 mg/mL (273.72 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Pureza y Documentación
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Ficha de datos (272 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Instrucciones de manejo (2659 KB)
Referencias
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.7372 mL | 13.6859 mL | 27.3718 mL | 68.4294 mL |
| 5 mM | 0.5474 mL | 2.7372 mL | 5.4744 mL | 13.6859 mL | |
| 10 mM | 0.2737 mL | 1.3686 mL | 2.7372 mL | 6.8429 mL | |
| 15 mM | 0.1825 mL | 0.9124 mL | 1.8248 mL | 4.5620 mL | |
| 20 mM | 0.1369 mL | 0.6843 mL | 1.3686 mL | 3.4215 mL | |
| 25 mM | 0.1095 mL | 0.5474 mL | 1.0949 mL | 2.7372 mL | |
| 30 mM | 0.0912 mL | 0.4562 mL | 0.9124 mL | 2.2810 mL | |
| 40 mM | 0.0684 mL | 0.3421 mL | 0.6843 mL | 1.7107 mL | |
| 50 mM | 0.0547 mL | 0.2737 mL | 0.5474 mL | 1.3686 mL | |
| 60 mM | 0.0456 mL | 0.2281 mL | 0.4562 mL | 1.1405 mL | |
| 80 mM | 0.0342 mL | 0.1711 mL | 0.3421 mL | 0.8554 mL | |
| 100 mM | 0.0274 mL | 0.1369 mL | 0.2737 mL | 0.6843 mL |
Cirtociclib Related Classifications
HY-160701 Related Classifications
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