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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
157 Results for "
coagulation factor
" in MedChemExpress (MCE) Product Catalog:
Products (157)
157 Results for "coagulation factor" in MCE Product Catalog:
61
61 Publications Verification
Synonyms: Sodium heparin; Sodium heparinate
Heparin sodium salt (Sodium heparin) is an anticoagulant which binds reversibly to antithrombin III (ATIII) and greatly accelerates the rate at which ATIII inactivates coagulation enzymes thrombin factor IIa and factor Xa. Heparin sodium salt significantly inhibits exosome-cell interactions.
20
20 Cited Publications
10
10 Cited Publications
Referencia número: HY-P1929
No. CAS: 128270-60-0
Target:
Áreas de investigación:
10
10 Cited Publications
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Áreas de investigación:
9
9 Cited Publications
Referencia número: HY-114164H
No. CAS: 9002-04-4
Synonyms: EC 3.4.21.5 (Lyophilized); Human Alpha Thrombin (Lyophilized)
Áreas de investigación:
Human α-Thrombin (EC 3.4.21.5; Human Alpha Thrombin) (Lyophilized) is a terminal serine protease in the coagulation cascade, as well as a potent physiological platelet agonist and fibrin-generating enzyme in vivo. Human α-Thrombin catalyzes the conversion of fibrinogen to fibrin for blood clot formation, and activates platelet aggregation by cleaving the protease-activated receptors PAR1 (major) (Kd = 1 nM) and PAR4 (minor) on the platelet surface to expose tethered ligands. Human α-Thrombin also amplifies coagulation via positive feedback by activating coagulation factors V, VIII, XI (FV/FVIII/FXI), and switches to activate protein C to exert anticoagulant effects after binding to thrombomodulin .
This product is in a freeze-dried form.
This product is in a freeze-dried form.
9
9 Cited Publications
Synonyms: DU-176
Áreas de investigación:
Edoxaban (DU-176b) is an orally active, highly potent, selective, and direct Factor Xa (FXa) inhibitor with Ki values of 0.561 and 2.98 nM for free human FXa and prothrombinase. Edoxaban exhibits more than 10,000-fold selectivity over other coagulation proteases. Edoxaban can be used in preventing thromboembolic disease research .
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9 Cited Publications
Synonyms: DU-176b
Áreas de investigación:
Edoxaban (DU-176b) tosylate is an orally active, highly potent, selective, and direct Factor Xa (FXa) inhibitor with Kis of 0.561 and 2.98 nM for free human FXa and prothrombinase. Edoxaban tosylate exhibits more than 10,000-fold selectivity over other coagulation proteases. Edoxaban tosylate can be used for preventing thromboembolic disease research .
9
9 Cited Publications
Synonyms: DU-176b monohydrate
Áreas de investigación:
Edoxaban (DU-176b) monohydrate is an orally active, highly potent, selective, and direct Factor Xa (FXa) inhibitor with Kis of 0.561 and 2.98 nM for free human FXa and prothrombinase. Edoxaban monohydrate exhibits more than 10,000-fold selectivity over other coagulation proteases. Edoxaban monohydrate can be used for preventing thromboembolic disease research .
5
5 Cited Publications
Synonyms: BAY-2433334
Target:
Áreas de investigación:
Asundexian (BAY 2433334) is an orally active coagulation factor Xia (FXIa) inhibitor. Asundexian binds directly, potently, and reversibly to the active site of FXIa and thereby inhibits its activity. Asundexian inhibits human FXIa in buffer with an IC50 of 1 nM .
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Target:
Áreas de investigación:
Gabexate mesylate (FOY) is is a competitive and non-antigenic synthetic inhibitor of trypsin-like serine proteinases. Gabexate mesylate inhibits human thrombin, urokinase, plasmin, and Factor Xa with Kis of 0.97, 1.3, 1.6, and 8.5 μM, respectively. Gabexate mesylate binds to human and bovine tryptase with Kis of 3.4 nM and 18 μM, respectively. Gabexate mesylate exerts an anticoagulant effect on the clotting activity of thrombin and has anti-inflammatory effect by viainhibition of NF-κB, proinflammatory cytokines, and nitric oxide. Gabexate mesylate is used for pancreatitis and disseminated intravascular coagulation .
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3 Cited Publications
Synonyms: Sodium heparin (MW 15kDa); Sodium heparinate (MW 15kDa)
Áreas de investigación:
Heparin sodium salt (MW 15kDa) (Sodium heparin (MW 15kDa)) is a polymer of Heparin with the molecular weight of 15kDa. Heparin sodium salt is an anticoagulant which binds reversibly to antithrombin III (ATIII) and greatly accelerates the rate at which ATIII inactivates coagulation enzymes thrombin factor IIa and factor Xa .
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2
2 Cited Publications
Synonyms: BMS-986177; JNJ-70033093
Target:
Áreas de investigación:
Milvexian is an orally bioavailable, small-molecule, reversible, direct antagonists of factor Xia, with the Ki of 0.11, 0.38, 0.64, 490, 350 nM for human, rabbit, dog, rat, mouse, respectively. Milvexian shows anti-thrombosis activity in vitro and in vivo, and can be used for thrombus study .
1
1 Cited Publications
Referencia número: HY-P4245
No. CAS: 88546-74-1
Target:
Áreas de investigación:
1
Target:
Áreas de investigación:
1
Target:
Áreas de investigación:
1
1 Cited Publications
Referencia número: HY-P701216
Pureza: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: F2; coagulation factor II (Thrombin); coagulation factor II, Thrombin; Prothrombin B-Chain; Prothrombin; F2 Protein; Prepro-coagulation factor II; RPRGL2; coagulation factor II; THPH1; Thrombin factor II; PT
1
1
1 Cited Publications
Referencia número: HY-P70231
Pureza: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: F9; Autoprothrombin IIA; coagulation factor IX; Coagulant factor IX; FIX; Christmas Disease; Plasma Thromboplastic Component; Hemophilia B; Plasma Thromboplastin Component; factor IX F9; Christmas factor; factor IX; PTC; factor 9; Truncated coagulation Fa
1
1 Cited Publications
Referencia número: HY-P74238
Pureza: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: F13B; Fibrin-Stabilizing factor B Subunit; coagulation factor XIII B Chain; Transglutaminase B Chain; FXIIIB; Alternative Protein F13B; Protein-Glutamine Gamma-Glutamyltransferase B Chain; TGase; coagulation factor XIII, B Polypeptide
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
