Prothrombin Protein, Human (HEK293, His)

Prothrombin or factor II is a key protein in a variety of physiological processes. The serine protease thrombin, derived from prothrombin, cleaves the bond behind arginine and lysine residues, converting fibrinogen to fibrin. Prothrombin Protein, Human (HEK293, His) is the recombinant human-derived Prothrombin protein, expressed by HEK293 , with C-10*His labeled tag.

The Prothrombin protein, also known as Factor II, serves as a critical player in various physiological processes. Thrombin, a serine protease derived from prothrombin, cleaves bonds following Arg and Lys residues, facilitating the conversion of fibrinogen into fibrin. Additionally, prothrombin actively participates in the activation of key factors such as V, VII, VIII, XIII, and, when in conjunction with thrombomodulin, protein C. Beyond its central role in blood homeostasis, prothrombin contributes significantly to inflammation and the intricate process of wound healing.

Human

HEK293

C-10*His

P00734 (M1-E622)

2147

Full Length

MAHVRGLQLPGCLALAALCSLVHSQHVFLAPQQARSLLQRVRRANTFLEEVRKGNLERECVEETCSYEEAFEALESSTATDVFWAKYTACETARTPRDKLAACLEGNCAEGLGTNYRGHVNITRSGIECQLWRSRYPHKPEINSTTHPGADLQENFCRNPDSSTTGPWCYTTDPTVRRQECSIPVCGQDQVTVAMTPRSEGSSVNLSPPLEQCVPDRGQQYQGRLAVTTHGLPCLAWASAQAKALSKHQDFNSAVQLVENFCRNPDGDEEGAWCYVAGKPGDFGYCDLNYCEEAVEEETGDGLDEDSDRAIEGRTATSEYQTFFNPRTFGSGEADCGLRPLFEKKSLEDKTERELLESYIDGRIVEGSDAEIGMSPWQVMLFRKSPQELLCGASLISDRWVLTAAHCLLYPPWDKNFTENDLLVRIGKHSRTRYERNIEKISMLEKIYIHPRYNWRENLDRDIALMKLKKPVAFSDYIHPVCLPDRETAASLLQAGYKGRVTGWGNLKETWTANVGKGQPSVLQVVNLPIVERPVCKDSTRIRITDNMFCAGYKPDEGKRGDACEGDSGGPFVMKSPFNNRWYQMGIVSWGEGCDRDGKYGFYTHVFRLKKWIQKVIDQFGE

Approximately 75-100 kDa, based on SDS-PAGE under reducing conditions.

• 
  ≥ 95%, as determined by reducing SDS-PAGE.

<1 EU/μg, determined by LAL method.